摘要
目的:探讨Cortactin(CTTN)蛋白在结直肠癌组织中的表达变化及其临床意义。方法:采用免疫组织化学法检测100例结直肠癌组织和癌旁正常组织中CTTN蛋白的表达情况,分析CTTN蛋白的表达变化与结直肠癌患者临床病理指标及预后的关系。结果:CTTN蛋白在结直肠癌组织中的阳性表达率为58%,显著高于癌旁正常组织的6%(P<0.01)。CTTN蛋白(<0.05)阳性表达率在不同的T分期(浸润深度)间的差异有统计学意义,而与患者的性别、年龄、肿瘤原发部位、肿瘤大小和淋巴结转移均无显著相关(P>0.05)。生存分析的结果显示,CTTN阳性患者的预后差于CTTN阴性患者(P=0.014)。结论:CTTN蛋白在结直肠癌中表达增加,并与结直肠肿瘤的浸润深度有关,可能作为结直肠癌预后判断的指标。
OBJECTIVE：To investigate the alteration of cortactin （CTTN） expression in colorectal cancer （CRC） and its correlation with clinico-pathological characteristics and prognosis. METHODS：Immunohistochemistry method was used to detect the expression of CTTN in 100 cases of CRC and adjacent normal tissues. The relationship between CTTN expression and clinico-pathological features and prognosis of the patients was evaluated. RESULTS：Positive rate of CTTN expression in colorectal cancer tissues was significantly higher than that in adjacent normal tissues （P〈0.01）. Expression of CTTN was correlated with depth of tumor invasion （P=0.037）. A Kaplan-Meier survival analysis revealed that the patients with CTTN expression had a shorter overall survival （OS） than those with negative CTTN （P=0.014）. CONCLUSION：CTTN overexpression was a common event,and seemed to be a poor prognostic factor for colorectal cancer.
出处
《癌变·畸变·突变》
CAS
CSCD
2014年第1期20-23,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
卫生行业公益专项(200902002-5)
863重大专项(2012AA022403
2012AA020206)
