摘要
目的:探讨卵巢交界性上皮性肿瘤(BOT)的临床情况及影响复发的有关因素。方法:回顾性分析我院诊治的58例BOT患者的临床资料及治疗结局。结果:58例患者的平均发病年龄为37.6岁;临床表现以无症状的盆腔肿块为主,共29例占50.00%;血清肿瘤标志物:CA125升高33例(56.90%),CA199升高20例(34.48%),两者比较差异有统计学意义(P<0.05)。所有患者均进行手术治疗,其中37例患者行保留生育功能手术。分期以Ⅰ期最多,占87.93%;浆液性和黏液性分别为25例和33例。术后随访8～68月,患者均存活;4例(6.90%)复发,肿瘤有微乳头或浸润性种植的患者复发率较高(P<0.05)。5例保留生育功能手术的患者在手术后正常妊娠并分娩。结论:BOT患者较年轻,以Ⅰ期为主,血CA125检测对诊断有帮助。手术是主要治疗手段,患者预后较好。其复发与肿瘤存在微乳头或浸润性种植可能有关。对其进行保留生育功能手术是安全有效的,术后需长期随访。
Objective：To evaluate the clinical features of borderline ovarian tumors （BOT） and to develop the potential prognostic factors of BOT. Methods：The clinical data of 58 patients with BOTS who were diag- nosed and treated in our hospital were retrospectively analyzed. Results：The mean age of BOT patients was 37.6 years. The main clinical feature of BOT is the symptomless pelvic cavity mass,which was found in 29 cases（50.00% of the cases）. 33 cases（56.90% ） had a raised blood CA12s level,and 20 cases（34. 48% raised in blood CA199 level（ P 〈 0.05）. All patients underwent surgery as the initial treatment, of whom 37 ca- ses underwent conservative surgery. Most of them were in FIGO stage ｜ （87.93%）. Duration of foUow-up was 8 ~68 months. 4 cases （6.90%） developed a recurrence. The recurrence rate of micro-papillary carci- noma or micro-invasive carcinoma cases were higher than others（ P 〈 0. 05）. Five patients underwent con- servative surgery had normal spontaneous delivery after normal pregnancy. Conclusions.. The clinical fea- tures of the borderline ovarian tumors is that most cases are young women,in FIGO stage I. CA12S can help to establish a diagnosis of BOT. Surgery is the main treatment of BOT,and patients have favorable prognosis after surgery. The recurrence of BOT may be related to micro-papillary carcinoma or micro-invasive carcino- ma. Conservative surgery is proved an effective and safe treatment for borderline ovarian tumors, and Iona-term follow-up is required.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2013年第10期765-768,共4页
Journal of Practical Obstetrics and Gynecology
