摘要
目的用超临界流体色谱法测定碘帕醇的对映异构体。方法采用Chiralpak OD-H手性色谱柱,以CO_(2^-)甲醇(89∶11)为流动相,检测波长为242 nm。结果 R-碘帕醇在0.2~1.2 mg·m L^(-1)内线性关系良好,精密度RSD为1.2%,回收率为103.7%(RSD=0.7%),且R-碘帕醇与S-碘帕醇分离度良好。结论本法快速、准确、可靠、专属性强,可用于碘帕醇中R-碘帕醇的控制。
OBJECTIVE To determine the enantiomer of Iopmamidol by a supercritical fluid chromatography（SFC） method. METHODS A Chiralpak OD-H chiral column was used, with CO_（2--）methanol mixture（89∶11） as the mobile phase, at the detection wavelength of 242 nm. RESULTS The linear calibration for the R-iopamidol was in the range of 0.2-1.2 mg·m L-（-1）, the precision was 1.2%, and recovery was 103.7%（RSD=0.7%）. Good resolution of R-iopamidol and its S-iopamidol was achieved. CONCLUSION The SFC method has been developed for quality control, and detection of R-iopamidol of iopamidol with sensitivity and specificity.
作者
杨杰锋
徐川龙
张洁
吴金韦
YANG Jiefengl XU chuanlong ZHANG Jiez WU Jlnwel(Zhejiang Province Medicine Economic Development Center, Hangzhou 310012, China Zhejiang Starry Pharmaceutical Co., Ltd., Taizhou 317300, China)
出处
《中国现代应用药学》
CAS
CSCD
2016年第12期1566-1569,共4页
Chinese Journal of Modern Applied Pharmacy
