摘要
目的:比较胰岛素静脉持续滴注与胰岛素泵持续皮下注射治疗糖尿病酮症酸中毒的临床疗效。方法:糖尿病酮症酸中毒住院患者70例随机分为观察组和对照组。对照组给予胰岛素静脉持续滴注,观察组给予胰岛素泵持续皮下注射。监测两组患者治疗后的空腹血糖、餐后血糖及血清氧化应激指标,并比较两组患者血糖达标时间、胰岛素用量、尿酮体转阴时间、p H恢复时间及并发症发生率。结果:观察组患者血糖达标时间明显短于对照组(P<0.05),胰岛素用量、尿酮体转阴时间及p H恢复时间等均明显低于对照组(P<0.05)。观察组患者治疗后SOD、MDA、GSH-PX及TAC水平均明显优于治疗前和对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率明显低于对照组(P<0.05)。结论:糖尿病酮症酸中毒急救中,胰岛素泵持续皮下注射可明显减少胰岛素用量,缩短血糖达标时间、尿酮体转阴时间及p H恢复时间,降低并发症发生率,值得临床推广应用。
Objective：To compare clinical efficacy of continuous intravenous insulin infusion and continuous subcutaneous insulin infusion in treatment of diabetic ketoacidosis. Methods： Totally 50 cases of patients with diabetic ketoacidosis were randomly divided into observation group and control group. Control group was treated by continuous intravenous insulin infusion, while observation group was treated by continuous subcutaneous insulin infusion. Fasting and postprandial blood glucose levels, oxidative stress related indicators of patients in two groups were monitored. Blood glucose target time, dosage of insulin, the urine acetone bodies＇ extinction time, pH recovery time and incidence of complications of patients in two groups were compared. Results：Blood glucose target time in observation group was significantly shorter than that in control group （P 〈 0.05 ）. Dosage of insulin, the urine acetone bodies＇extinction time and pH recovery time in observation group were significantly lower than those in control group （ P 〈 0.05 ）. After treatment , SOD, MDA, GSH-PX and TAC lev- els of patients in observation group were significantly better than before treatment and control group （ P 〈 0.05 ）. Total incidence of complications in observation group was significantly lower than that in control group （P 〈 0.05 ）. Conclusion： Continuous subcutaneous insulin infusion in treatment of diabetic ketoacidosis could reduce dosage of insulin, shorten blood glucose target time, the urine acetone bodies＇extinction time and pH recovery time, and reduce incidence of complications. It was worthy of wide spread application in clinical practice.
出处
《药物流行病学杂志》
CAS
2015年第10期591-593,共3页
Chinese Journal of Pharmacoepidemiology
关键词
糖尿病酮症酸中毒
持续皮下注射
静脉持续滴注
胰岛素泵
Diabetic ketoacidosis
Continuous subcutaneous infusion
Continuous intravenous infusion
Insulin pump
