摘要
目的:比较不同胰岛素给药方法对糖尿病酮症酸中毒的疗效差异。方法:将住院糖尿病酮症酸中毒患者随机分成持续皮下胰岛素泵治疗组(CS II组)22例和常规小剂量胰岛素静脉滴注组(对照组)18例。观察两组患者血糖、血酮、尿酮变化及低血糖的发生率。结果:两组患者的血糖经治疗后均有明显下降,达目标血糖值所需时间:对照组为(4.4±2.1)h,比CS II组(5.5±2.9)h要短,但无显著差异(P>0.05)。CS II组血酮转阴时间(3.5±0.7)d,较对照组(4.5±0.5)d明显缩短,具有显著差异(P<0.001);尿酮转阴时间(29.1±11.3)h,亦较对照组(42.2±9.2)h明显缩短,差异具有显著性(P<0.001),CS II组低血糖发生率(0.9±0.3)次/人,较对照组(2.1±0.4)次/人明显减少,具有显著性差异(P<0.001。结论:胰岛素泵持续皮下输注胰岛素治疗糖尿病酮症酸中毒较常规小剂量静脉滴注胰岛素更安全有效。
Objective To compare the effect of two different ways of insulin delivery on diabetic ketoacidosis. Methods Forty patients with diabetic ketoacidosis were divided into two groups, 22 cases treated with insulin pump （CSⅡ group） and 18 cases treated with low dose intravenous infusion （control group ）. The average recovering time of blood glucose, blood ketoacidosis urinary ketoacidosis and the frequency of hypoglycemia incidences were observed in two groups. Results The level of blood glucose control in two groups was similar after treatment. It took （4.4±2.1） hours in CSⅡ group and （5.5±2.9）hours in control group to recover blood glucose. There was a significant difference in two groups of the recovery time of blood ketoacidosis （P〈0.01）. It took （29.1± 11.3） hours in CSⅡ group and （42.2±9.2） hours in control group to reverse the urinary ketiacidosis （P± 0.01）. The frequency of hypoglycemia incidence in CSⅡ group was （0. 9±0.3） times/case and （2.1± 0.4） times/case in control group （P〈0. 01）. Conclusion The insulin pump is more effective and safe than intravenous insulin infusion in the patients with diabetic ketoacidosis.
出处
《实用诊断与治疗杂志》
2006年第9期647-648,650,共3页
Journal of Practical Diagnosis and Therapy
关键词
糖尿病
胰岛素泵
酮症酸中毒
Diabetes mellitus
insulin pump
diabetic ketoacidosis
