摘要
目的:比较普通胰岛素与速效胰岛素类似物(诺和锐)治疗糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)的疗效和安全性。方法:将37例住院DKA患者分为普通胰岛素治疗组(RI组)20例和胰岛素类似物治疗组(NR组)17例,对比2组间血糖、血糖达标时间、血糖达标时胰岛素用量、尿酮变化、血液酸碱度及治疗过程中低血糖的发生次数,探讨DKA治疗方案。结果:2组患者的血糖治疗后均明显下降,NR组治疗DKA所用胰岛素总量显著低于RI组(P<0.01);尿酮转阴时间及纠正酸中毒所需时间,NR组与RI组差异无显著性;NR组低血糖发生次数显著少于RI组(P<0.01)。结论:糖尿病酮症酸中毒治疗过程中,在无差异的血糖达标时间内,静脉泵注入速效胰岛素类似物较普通胰岛素降糖时所用胰岛素量更小,低血糖发生次数更少,具有更优的疗效和安全性。
OBJECTIVE To compare the efficacy and safety of regular insulin（RI） and rapid insulin analogues（Insulin Aspart Injection, NR） on diabetic ketoacidosis（DKA）. METHODS 37 patients with diabetic ketoacidosis were randomized into RI group （n = 20,treated with regular insulin） and NR group （n = 17, treated with Insulin Aspart Injection）. The dose of insulin needed for good control of glycemia,the average recovering time of urinary ketoaeidosis, the change of blood pH and the fre- quency of hypoglycemia were observed in two groups. RESULTS The levels of glycemia were declined obviously in both groups. Both groups reached the dose of insulin needed for good control of glycemia, the average amount of insulin needed in NR group was obviously less than that in RI group （P^0.01）. There were no significantly differences in the average recove- ring time of urinary ketoacidosis and blood pH between the two groups （P^0. 05）. There was a significant reduction in the frequency of hypoglycemia in NR group（P^0. 01） comparing with RI group. CONCLUSION In the treatment of diabetic keto acidosis,the dose of insulin analogues needed by vena pump was less than regular insulin in no different time that glycemia downs to standard, and the frequency of hypoglycemia is lower in NR grourp. Therefore, rapid insulin analogues was safer and more effective than regular insulin in the treatment of diabetic ketoacidosis.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第21期1837-1839,共3页
Chinese Journal of Hospital Pharmacy
