摘要
目的:研究胰腺癌组织中Survivin和MMP14的表达及其临床病理意义,为筛选胰腺癌分子诊断新靶标提供理论依据。方法:采用免疫组织化学技术(S-P)法检测44例胰腺癌、13例胰腺炎及21例正常胰腺组织中Survivin和MMP14表达情况,并分析其与胰腺癌临床病理参数的相关性。结果:胰腺癌组织中Survivin和MMP14蛋白均呈明显高表达,其表达与胰腺癌患者的性别、年龄、肿瘤部位、临床分期、分级及有无淋巴结转移均显著相关性(P>0.05)。胰腺炎与正常胰腺组织中Survivin和MMP14蛋白表达的差异无统计学意义(P>0.05),但均显著低于胰腺癌组织(P=0.000/P=0.001)。结论:Survivin和MMP14蛋白在胰腺癌组织中均呈异常高表达,但与胰腺癌的临床病理特点均无关,可能成为新的胰腺癌诊断标志物。
Objective： To study the expression and clinical significance of Survivin and MMP14 in pancreatic cancer, and to provide valuable evidences for finding new diagnostic markers for pancreatic cancer. Methods： The expression levels of Survivin and MMP14 were detected by S-P immunohistochemistry in 44 cases of pancreatic cancer, 13 cases of pancreatitis and 21 cases of normal pancreas tissue. The relationship between their expressions and clinic-pathological features of pancreatic cancer were also analyzed.Results： The expression of Survivin and MMP14 were both significantly higher in pancreatic cancer than those in pancreatitis and normal pancreas tissue. Both the expression of Survivin and MMP14 had no relationship with the sex, age, location, histologic grade, stage or metastasis of lymph nodes of patients with pancreatic cancer（P〉0.05）. Furthermore, the expression of Survivin and MMP14 had no significantly statistical difference between pancreatitis and normal pancreatic tissues（P〉0.05）, which were significantly lower than those of the pancreatic cancer（P=0.000/P=0.001）. Conclusions： The expression of Survivin and MMP14 in pancreatic cancer were both higher than those in non-tumorous pancreas tissue, which had no correlation with the clinic-pathological features of pancreatic cancer. Survivin and MMP14 could become the new diagnostic markers for pancreatic cancer.
出处
《现代生物医学进展》
CAS
2015年第16期3022-3027,共6页
Progress in Modern Biomedicine
基金
国家自然科学基金重大合作项目(81220108011)
国家自然科学基金项目(81370039)
