摘要
胰腺癌是一种恶性度极高的消化系统肿瘤,其早期症状隐匿,发现时多已是晚期,手术切除率低,预后差.随着人类生活习惯与饮食结构的改变,胰腺癌的发病率在全球范围内逐年上升.胰腺癌发病是遗传因素和环境因素相互作用的结果,其可能与基因突变、基因多态性、表观遗传等因素引起的遗传易感性提高有关.某些与胰腺癌相关的危险因素诸如吸烟、肥胖、饮酒、慢性胰腺炎、糖尿病等已越来越受到广泛关注.因此,了解胰腺癌流行病学和病因学的发展将有助于更好地认识这种疾病,具有重要的意义.
Pancreatic cancer is a life-threatening digestive system neoplasm with a low rate of surgical resection and poor prognosis. Symptoms of pancreatic cancer are so insidious that it is difficult to identify them at early stage. Due to changes in human lifestyle and diet, the incidence of pancreatic cancer has been increasing worldwide. Both genetic and environmental factors contribute to the pathogenesis of pancreatic cancer. Some hereditary factors, such as genetic mutations, genetic polymorphisms and epigenetics, have been demonstrated to be related to the development of pancreatic cancer. Many risk factors associated with pancreatic cancer, such as smoking, obesity, alcohol consumption, chronic pancreatitis, and diabetes, have also been identified. Here we vances in understanding review the recent adthe epidemiology andetiology of pancreatic cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第27期2805-2809,共5页
World Chinese Journal of Digestology
基金
黑龙江省教育厅科学技术研究资金资助项目
No.12511247~~
关键词
胰腺癌
流行病学
病因学
Pancreatic cancer
Epidemiology
Etiology
