摘要
目的 :观察高血压左室肥厚 (LVH)与血压昼夜节律关系及比索洛尔对其影响。方法 :4 5例原发性高血压 (EH)伴LVH患者服药前行动态血压及超声心动图检测 ,并于服药后 8周进行复查比较。结果 :血压昼夜节律消失组 30例 ,血压昼夜节律正常组 15例。血压昼夜节律消失组 2 4h收缩压、夜间血压、血压负荷均高于血压昼夜节律正常组。昼夜节律消失组服用比索洛尔 8周后 ,昼夜节律、室间隔厚度、左室后壁厚度、左室重量指数、舒张晚期血流峰速、等容舒张时间均有明显改善 ,血压昼夜节律正常组左室功能也有改善。结论 :高血压LVH患者血压昼夜节律消失多见 ,索他洛尔可使血压昼夜节律趋于正常 。
Objective:To study the effects of Bisoprolol on hypertension associated left ventricular hypertrophy and circadian rhythm of blood pressure.Method:Fourty five patients of hypertention with left ventricular hypertrophy were selected for ABPM and UCG before and after Sotalol taken.Result:Abnormal circadian rhythms were found in 30 patients (group A), normal in group B. 24 h SBP、nBP and BP load were higher in group A. 8 weeks after bisoprolol therapy, IVST、PWT、LVMI、AP and IRT were improved distinctly in group A. The LV function were also improved in the patients with normal circadian rhythm.Conclusion:Abnormal circadian rhythm were discovered frequently in the patients with hypertention and LV hypertrophy. Bisoprolol could recover abnormal circadian rhythm and improve the LV function.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第6期266-268,共3页
Journal of Clinical Cardiology
关键词
高血压
左室肥厚
血压昼夜节律
比索洛尔
Hypertension
Left ventricular hypertrophy
Hypertension circadian rhythm
Bisoprolol
