摘要
丹参素是从丹参的水溶性酚性酸中提取出的R(+)-3,4-二羟基苯基乳酸的钠盐。它是丹参水溶性成分中抗心肌缺血的主要成分,有扩张血管、增加冠脉流量等作用。仅从丹参植物中提取有效成分有局限性,同时丹参素的结构极易氧化,因此薛芬,董纪昌等改进合成了消旋的丹参素和几个取代苯基乳酸。从中筛选到苯基乳酸有较强抑制血小板聚集和抑制微循环障碍的作用,现正进行临床药理试验。
This paper describes the synthesis of α - nicotinyloxy -β- (substituted phenyl ) propionic acid and α - (o - acetoxy ) benzoyloxy -β - phenyl propionic acid. They were obtained in six steps starting from benzaldehyde or substituted benzaldehyde. The preliminary pharmacological tests show that all compounds were effective for inhibition of rabbit platelet aggregation.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第7期552-556,共5页
Acta Pharmaceutica Sinica
基金
卫生部科学基金
关键词
丹参素衍生物
合成
Danshensu
Clemmensen reduction
α-Nicotinyloxy -β - (substituted phenyl) propionic acid
α - (o-Acetoxy) benzoyloxy-β- phenyl propionic acid
