摘要
目的 探讨热休克蛋白 70 (HSP70 )在非小细胞肺癌(NSCL C)的表达及意义 .方法 采用 SABC免疫组织化学方法检测了 A 期 NSCL C5 6例、转移灶及其癌旁组织中HSP70的表达 .结果 HSP70在癌组织中的表达阳性率为87.5 % (49/ 5 6 ,腺癌 2 1/ 2 7,鳞癌 2 8/ 2 9) ,HSP70在转移癌组织中的表达阳性率为 91.1% (5 1/ 5 6 ) ,而在癌旁的肺组织HSP70的表达阳性率为 10 .7% (6 / 5 6 ) ,癌组织的表达阳性率明显高于癌旁组织 (P<0 .0 1) ;癌组织与转移灶的表达阳性率比较无显著性差异 (P >0 .0 5 ) .结论 HSP70在 NSCL C高表达可能通过细胞的生长调控在肿瘤的发生过程中具有重要作用 .
AIM To study the expression and significance of HSP70 in non small cell lung cancer. METHODS The expression of HSP70 among lung cancer, metastasis and para carcinoma tissues in 56 patients with non small cell lung cancer was examined and compared by using immunohistochemical SABC method. RESULTS The positive staining rates of HSP70 in the carcinoma, metastasis and para carci noma tissues were 87.5% (49/56, adenocarcinoma 21/27, squamous carcinoma 28/29), 91.1% (51/56) and 10.7% (6/56), respectively. There was statistical significance between the positive staining rate in carcinoma and para carcinoma tissues ( P <0.01); however, no significance was found between that in carcinoma and metastasis tissues ( P >0.05). CONCLUSION The over expression of HSP70 in non small cell lung cancer tissues might play an important role in the process of oncogenesis by influencing the cellular growth control.
出处
《第四军医大学学报》
北大核心
2002年第9期825-826,共2页
Journal of the Fourth Military Medical University
关键词
HSP70
肺癌
癌旁组织
转移灶
表达
heat shock protein
non small cell lung cancer
immunohistochemistry
