摘要
目的研究上皮-间质转化现象调节基因Nodal在肝细胞癌中的表达及其意义。方法采用免疫组织化学染色法检测Nodal蛋白在肝癌组织、肝炎肝硬化组织和癌旁肝组织的表达。结果在95例肝细胞癌组织中,59例(62.1%)Nodal蛋白阳性,20例癌旁肝组织中4例(20.0%)阳性,12例肝炎肝硬化组织中2例(16.7%)阳性;Nodal蛋白表达的患者,肿瘤组织直径较大、血管侵袭率较高、Edmondson分级较高、TNM分期较晚(P<0.05)。结论Nodal与肝细胞癌的发生发展有关,可能作为肝细胞恶性变的重要预测指标。
Objective To study the expression of Nodal in hepatocellular carcinoma and its significance： Methods The Nodal protein expression in 95 hepatocellular carcinoma,20 adjacent liver cirrhosis and 12 liver cirrhosis was detected by immunohistoehemieal staining.Results There was 59 cases （62.1%）with positive expres- sion of Nodal in 95 patients with hepatoeellular carcinoma,while 4（20.0%）in 20 adjacent liver tissues,and 2（16.7%） in 12 cirrhosis tissues; Meanwhile i patients with Nodal expression had large tumors,higher rate of vascular invasion, higher Edmondson grades and later TNM stages （P〈0.05）.Condusion Nodal may be related to the development of hepatocellalar carcinoma,and might be an important predictor of malignant progression.
出处
《实用肝脏病杂志》
CAS
2012年第1期37-39,共3页
Journal of Practical Hepatology
基金
国家自然科学基金面上项目(30972892)
安徽省2011年度科技计划项目(1106c0805028)
安徽省"115"产业创新团队-肝细胞癌转移复发研究团队资助项目
