摘要
目的 研究金属硫蛋白（ＭＴ）基因在上皮性卵巢肿瘤中的表达及临床意义。方法 采用ＳＡＢＣ免疫组化法，对７２例上皮性卵巢肿瘤中金属硫蛋白的表达进行检测。结果 恶性肿瘤、交界性肿瘤和良性肿瘤 ＭＴ的表达分别为 ６４． ４％、３０．０％和 １１．８％，恶性肿瘤、交界性肿瘤 ＭＴ的表达明显高于良性肿瘤（分别为Ｐ＜０．０１和Ｐ＜０．０５）。随肿瘤组织病理分级及临床分期的增高，ＭＴ的表达也增加（Ｐ＜０．０５）。ＭＴ高表达者的生存期明显缩短。结论ＭＴ参与了上皮性卵巢恶性肿瘤的发生与发展，并有可能成为一个判定预后的有效指标。
Aim To examine the expression of metallothionein gene in epitheliol ovarian tumor and to explore its relationship with tumorigenesis. Methods MT expression in 72 ovarian tumor tis- sues was detected by SABC immunohistochemical staining. Results The positive rates of MT expression in malignant, borderline and benign tumors were 64.4%, 30.0% and 11. 8%, respectively. The MT expression in malignant and bordline tumor were obviously higher than that in benign tumors ( P <0. 01). MT expression in- creased with advancement clinical stage and pathological grading of tumor tissue. Lymph node metastasis correlated with MT expression (P <0. 05). The survival period of the patients with high MT ex- pression was shorter. than that of the patients with cow MT express- lon. Conclusion MT expression may play an important role in genesis and progression of malignant epithelial ovarian tumor. Thus MT is promising as an index of determining patient's prognosis.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2002年第1期41-42,共2页
Chinese Journal of Cellular and Molecular Immunology
