摘要
目的 探讨甲状腺肿瘤组织中雌激素受体 (ER)、孕激素受体 (PR)的表达与肿瘤浸润转移的关系。方法 应用SABC免疫组化法 ,对 10 0例甲状腺癌及 2 8例甲状腺良性肿瘤中ER、PR进行检测。结果 甲状腺癌中ER、PR阳性表达分别为 6 7.0 %和 6 2 .0 % ,均与细胞分化程度、组织学类型有关 ,但其阳性表达与年龄、性别无关。ER、PR在无淋巴结转移组的甲状腺癌中阳性率为 75 .4%和 70 .5 % ,显著高于有转移组的 5 3 .8%和 48.7% (P <0 .0 5 )。结论 ER。
HT6”,5”] [WT5”BZ] [WT5”HZ]Objective [WT5”BZ]To study the relations between the expression of estrogen receptor (ER), progesterone receptor (PR) and tumor infiltration and metastasis in thyroid carcinoma. [WT5”HZ]Methods [WT5”BZ]By using immunohistochemical staining (SABC method), the expressions of ER and PR in 100 cases of thyroid carcinomas and 28 cases of benign thyroid lesions were studied. [WT5”HZ]Results [WT5”BZ]The positive rate of ER and PR expressions were 67.0% and 62.0% respectively in thyroid carcinomas, they had correlation with cell differentiation and type of histology but positive expressions did not relate to age and sex. The positive rate of ER and PR in the non metastasized group was 75.4% and 70.5%, significantly higher than that of the metastasized group in which were 53.8% and 48.7% ( P <0.05). [WT5”HZ]Conclusion [WT5”BZ]The results suggest that the expressions of ER and PR are related to tumor differentiation and may indicate a poor prognosis. [HT6,5”] [WT5”HZ]
出处
《中国普外基础与临床杂志》
CAS
2000年第5期311-312,共2页
Chinese Journal of Bases and Clinics In General Surgery
