摘要
目的 :探讨不同频率的电针能否减轻大鼠神经源性痛。方法 :将大鼠右侧L5 /L6脊神经结扎 ,用引起 5 0 %抬足的机械刺激阈值评价机械性痛觉超敏 ,用大鼠 5min内从 5℃冷板上的抬足次数反映冷诱发的持续性疼痛。用韩氏穴位神经刺激仪给与 2Hz或 10 0Hz电刺激。结果 :① 2Hz和 10 0Hz电针均能减轻痛觉超敏 ,2Hz起效较早。②两种频率电针均能减轻冷诱发的持续性疼痛 ,但 2Hz持续的时间长 ,多次电针后 2Hz的镇痛效果可持续长达 4 8h。③针刺而不通电也能显著减轻冷诱发的持续性痛。结论 :电针能减轻神经源性痛 ,且低频 (2Hz)电针的镇痛效果优于高频 (10 0Hz)电针。
Aim:Our previous studies showed that electroacupuncture (EA) could inhibite radiant heat induced pain and acute or chronic inflammatory pain in rats. In the present study, we observed whether EA with different frequencies could suppress neuropathic pain. Methods:L5/L6 nerve ligation model was used to assess the effect of EA on neuropathic pain. Mechanical allodynia was represented by 50% withdrawal threshold, while cold induced ongoing pain was detected by the number of paw lift in 5 min when the rat was put on a 5℃ cold plate. Han’s acupoint nerve stimulator (HANS) was connected to needles inserted into acupoints “jiaji”and “Zusanli” in both sides. The parameters were: (intensity: 0.5 1 2 mA, 10 min each; frequency 2 Hz or 100 Hz; pulse width: 0.6 ms for 2 Hz, 0.2 ms for 100 Hz).Results: EA of both 2 Hz and 100 Hz could relieve the mechanical allodynia, where 2 Hz could induce the effect with shorter latency; they could also relieve the cold induced ongoing pain, where the effect of 2 Hz outlasted the EA session by up to 48 h after repetitive stimulations over several weeks; a significant relieving effect on cold induced ongoing pain could also be induced by needle insertion without stimulation. Conclusion: EA could relieve neuropathic pain, the analgesic effect of 2 Hz EA is higher than 100 Hz EA.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2002年第2期128-131,共4页
Chinese Journal of Applied Physiology
基金
国家基础研究重大课题 (G19990 5 40 0 0
国家自然科学基金 (3 983 0 160 3 980 0 1983 970 0 188)
美国NIH基金(DA0 3 983 )
