摘要
四氯化碳（ＣＣｌ４）致大鼠慢性肝损害，用肝勃宁（ＧＢＮ）２．３１，０．７７，０．２６ｇ／ｋｇ分别给大鼠每天１次ｉｇ，连续４５天。经病理学检查显示能减轻肝纤维化程度，肝脂肪变、嗜酸性坏死发生率明显减少；血清总蛋白量增高，ＳＧＰＴ、ＳＧＯＴ、唾液酸浓度、羟脯氨酸含量下降。结果表明ＧＢＮ对ＣＣｌ４致大鼠慢性肝损害有一定保护作用。
The rat with chronic hepatic injury induced by CCl 4 were treated with Ganbonin ig in the doses of 2.31g/kg,0.77g/kg,0.26g/kg per day for 45 consecutive days respectively.Histopathological examinations showed the reduced degrees of chronic fibrosis and remarkable reduced incidence of focal necrosis and fatty degeneration of the liver.Other examinations found that Ganbonin could increase total serum proteins and decrease contents of serum GOT,GPT,Sialic acid and hepatic hydroproline.These results suggest that Ganbonin can partially protect the rats from suffering chronic injury by CCl 4.
出处
《中药药理与临床》
CAS
CSCD
1998年第1期38-40,共3页
Pharmacology and Clinics of Chinese Materia Medica
