摘要
[目的]探察小柴胡汤的降脂及抗脂肪肝形成的作用。[方法]SD大鼠连续给予脂肪乳剂灌胃造模后分成模型组、小柴胡汤小、大剂量组、辛伐他汀组,各组继续给予脂肪乳剂灌胃,其中小柴胡汤小、大剂量组予小柴胡汤中药灌胃,辛伐他丁组给予辛伐他丁溶液灌胃,观测各组大鼠血脂、肝重及肝HE的变化。[结果]模型组大鼠给予脂肪乳剂灌胃1w后,血脂较正常组显著升高(P<0.01或P<0.05),3w后血脂持续升高、肝脏指数增加及出现脂肪变。与模型组比较,各给药组大鼠血脂、肝脏指数及肝脂肪变程度均呈不同程度的降低,其中小柴胡汤大剂量组和辛伐他汀组的作用较明显。[结论]小柴胡汤具有一定的降脂及抗肝脂肪变的作用。
[Objective] To explore the function of Small Bupleurum Decoction on reducing lipid and anti fat liver.[Method] After successively making stomach perfusion of fat emulsion to make SD rats model,then randomly divide into model group,Small Bupleurum Decoction small-dosage,big-dosage groups and Simvastatin group;successively make corresponding perfusion;observe their lipid,liver weight and HE change.[Result] After 1w,in model group,the lipid is much more than before,after 3w,it rises continuously,so is liver index,the fat lesion begins;compared to model group,other groups indexes are in different reduction,among which,the big-dosage group and Simvastatin groups have more obvious change.[Conclusion] The decoction has definite lipid reduction and anti fat liver function.
出处
《浙江中医药大学学报》
CAS
2010年第1期54-55,57,共3页
Journal of Zhejiang Chinese Medical University
关键词
高脂血症
小柴胡汤
降脂
抗肝脂肪变
动物模型
hyperlipemia
animal model
Small Bupleurum Decoction
lipid reduction
anti liver fatty change
