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胃癌组织中PCNA与微血管密度相关性的研究 被引量:2

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摘要 目的 :研究胃癌组织中增殖细胞核抗原 (PCNA)与微血管密度 (MVD)的表达情况及其相关性。方法 :选取 6 0份胃癌组织作为实验组 ,同时取 2 0份远癌旁胃黏膜作为对照组 ,用免疫组化SP法检测其PCNA和MVD的表达。结果 :( 1) 6 0份胃癌组织中的PCNA指数平均值为 ( 4 2 0 0± 17 41) % ,MVD均值为 10 0 7± 5 2 3,均显著高于对照组。 ( 2 )PCNA与MVD比较 ,两者呈正相关 (r =0 5 98,P <0 0 0 1)。结论 :胃癌组织中存在有PCNA与MVD的高表达 ,且PCNA与MVD具有相关性 ,反映胃癌细胞增殖活跃 ,正反馈促进肿瘤MVD的增高 ,而使胃癌不断增生和扩张。
出处 《实用医学杂志》 CAS 2002年第1期28-29,共2页 The Journal of Practical Medicine
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  • 1[1]Maeda K,Chung YS,Takatsuka S,et al.Tumor angiogensis and tumor cell proliferating as prognostic indicators in gastric carcinoma.Br J Cancer,1995,72(3):319~323.
  • 2[2]Dierendonck JH,Wijsman JH,Keijer R,et al.Cell-cycle-related staining patterns of antiproliferating cell nuclear antigenmonoclonal antibodies: comparison with Brd Urd labeling and Ki-67 staning.Am J Pathol,1991,138(5):1165~1172.

同被引文献17

  • 1Yang ZF, Poon RT. Vascular changes in hepatocellular carcinoma[ J]. Anat Rec ( Hoboken ) ,2008,291 ( 6 ) :721 - 734.
  • 2Roberta P, Ronnie TP. Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma[ J ]. Cancer Letters ,2006,242 (2) : 151 - 167.
  • 3Venturi A,Piaz FD,Giovannini C,et al. Human hepatocellular carcinoma expresses specific PCNA isoforms : an in vivo and in vitro evaluation [ J ]. Lab Invest,2008,88 ( 9 ) :995 - 1007.
  • 4Mun KS, Cheah PL, Baharudin NB, et al. Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri -neoplastic and normal liver[ J ]. Malays J Pathol,2006,28 (2) :73 - 77.
  • 5Weidner N. Measuring intratumoral microvessel density [ J ]. Methods Enzymol, 2008,44 (4) : 305 - 323.
  • 6Xiang Z,Zeng Z,Tang Z, et al. Increased expression of vascular endothelial growth factor - C and nuclear CXCR4 in hepatocellular carcinoma is correlated with lymph node metastasis and poor outcome[ J]. Cancer J,2009,15 ( 6 ) :519 - 525.
  • 7汪希明,郑树,丁仁瑞.肿瘤生物学[M].浙江:浙江科学技术出版社,1990.34-39.
  • 8Kawai T,Suzuki M,Kono S,et al.Proliferating cell nuclear antigen and Ki-67 in lung carcinoma Correlation DNA flow cytometric analysis[J].Cancer,1994,74(9):2469-2475
  • 9Michalides R,Veelen NV,Hant A,et al.Overexpression of cyclinD1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck[J].Cancer Res,1995,55(5):975-978
  • 10Marx J.Howcells Cycle Toward Cancer[J].Science,1994,263(5145):319-321

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