摘要
目的探讨尿核基质蛋白22（NMP22）与膀胱移行细胞癌病理分级分期的关系。方法对1999年6月至2005年3月间就诊的642例膀胱癌患者行尿液NMP22检测，检测后1周-1个月内行膀胱镜和病理学检查，按病理分级分为3组，G1组为69例（男58例、女11例），G2组为375例（男255例、女120例），G3组为198例（男143例、女55例），比较中位数NMP22浓度。同时，对其中239例患者按病理分期分为3组，PT1组为121例（男76例、女45例），PT2组为65例（男37例、女28例），PT3组为53例（男36例、女17例），比较中位数NMP22浓度。结果G1、G2和G3组之间中位数NMP22浓度比较，差异有统计学意义（X^2=67．547，P〈0．001）；PT1、P12和PT3组之间中位数NMP22浓度比较，差异有统计学意义（X^2=20．629，P〈0．001）。结论尿NMP22浓度与膀胱移行细胞癌的病理分级、分期有相关关系。
Objective To assess the relationship between nuclear matrix protein（NMP） 22 urinary level and the grade and stage of bladder transitional cell carcinoma. Methods From June 1999 to March 2005 642 patients underwent NMP22 test ,and then the test by cystoscope and pathology were performed in 1 week to 1 month. According to the pathological grade,the patients were divided into 3 groups： group G1 ： 69 cases, male 58 and female 11 ; group G2 ： 375 cases, male 255 and female 120; group G3 ： 198 cases, male 143 and female 55. And the difference of NMP22 between each group were compared . Meanwhile, according to pathological stage, 239 patients were divided into 3 groups： group PT1： 121 cases, male 76 and female 45 ; group PT2：65 cases, male 37 and female 28; group PT3：53 cases, male 29 and female 24. And the difference of NMP22 between each group were compared . Results The concentrations of NMP22 had significant difference between the 3 groups which divided according to pathological grade （Kruskal- Wallis test X^2 =67. 547 ,P 〈0. 001 ） ; The concentrations of NMP22 had significant difference between the 3 groups which divided according to pathological stage （ Kruskal-Wallis test X^2 = 20. 629, P 〈 0. 001）. Conclusions There is a relation between NMP22 urinary level and the grade and stage of bladder transitional cell carcinoma.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2006年第10期681-683,共3页
Chinese Journal of Surgery
关键词
核蛋白类
膀胱肿瘤
细胞分化
肿瘤分期
Nucleo proteins
Bladder neoplasms
Cell differentiation
Neoplasm staging
