摘要
目的 :研究盐酸特比萘芬体外经皮渗透性及丙二醇和氮酮对其经皮渗透性的影响。方法 :采用改良Franz式扩散池 ,考察盐酸特比萘芬及在不同浓度丙二醇和氮酮以及两者合用时的渗透效果。结果 :盐酸特比萘芬有较好的经皮渗透性 ;1 %丙二醇可提高其经皮渗透性能 (P <0 .0 5) ,3 %丙二醇起抑制作用 (P <0 .0 5) ,2 0 %丙二醇抑制作用更强 (P <0 .0 1 ) ;1 % ,3 %氮酮可增强其经皮渗透性 (P <0 .0 1 ) ;1 %氮酮与 2 0 %丙二醇合用则显著抑制其经皮渗透性(P <0 .0 1 )。结论 :盐酸特比萘芬有较好的体外经皮渗透性能。
Objective:To study the in vitro percutaneous permeability of terbinafine hydrochloride and the effect of propylene glycol and azone on the permeabilility. Methods:With the use of the modified Franz's type diffusion cell and 0.1 mol·L 1 hydrochloric acid solution as the receptor medium, an observation was made on the in vitro percutaneous permeability of terbinafine hydrochloride. The effects of propylene glycol and/or azone on in different concentrations the percutaneous permeabilility of terbinafine hydrochlorode were also studied. Results:Terbinafine hydrochloride itself had a good property of in vitro percutaneous permeability, which could be increased by 1% propylene glycol(P<0.05) and inhibited by 3% propylene glycol(P<0.05). 20% propylene glycol displayed a still stronger inhibitory effect(P<0.01). Both 1% and 3% azone could increase the percutaneous permeability(P<0.01), which, in turn, could be inhibited by the combined effect of 1% azone and 20% propylene glycol (P<0.01). Conclusion: Terbinafine hydrochloride has a relatively good property of in vitro percutaneous permeability that can be affected by propylene glycol/azone in different concentrations.
出处
《医药导报》
CAS
2002年第1期13-14,共2页
Herald of Medicine
关键词
盐酸特比萘芬
体外
经皮渗透性
实验研究
抗真菌药
Percutaneous permeability, in vitro
Terbinafine hydrochloride
Propylene glycol
Azone
