摘要
目的比较研究两家企业生产的盐酸特比萘芬乳膏对离体小型猪皮的透皮吸收性能。方法采用改良的Franz扩散池，离体小型猪皮片涂药后不同时间采样，用高效液相色谱法测定接收液和皮片中盐酸特比萘芬的浓度。结果盐酸特比萘芬乳膏透皮释放量很低，在80％乙醇生理盐水释放液中，某企业生产的乳膏产品和中关天津史克制药有限公司生产的乳膏产品在48h时累积透皮渗透量分别为55．23mg／cm2和63．33mg／cm2，48h的累积透过率分别为：1．09％、1．19％。结论两家企业生产的乳膏产品在相同渗透介质下，对于离体小型猪皮的透皮无显著性差别，二者透皮情况相当。盐酸特比萘芬乳膏主成分大部分滞留在皮肤上，只有极少数透过皮肤屏障，有利于其发挥局部治疗作用。
Objective To study the percutaneous absorption of terbinafine hydrochloride cream through in vitro Tibet minipig＇s skins, and compare the penetration absorption of domestic certain enterprise product with GlaxoSmithKline china product. Methods Using the modified Franz diffusion cell, samples were collected at different time after the drug was applied. The concentration of terbinafine hydrochloride in the samples was measured by HPLC. Results The penetration release quantities of terbinafine hydrochloride across Tibet minipig skins in 80% ethanol saline solution in 48h were very low, only 63.33 mg .cm-2 for GlaxoSmithKline China product, and 55.23 mg. cm-2 for certain enterprise product, and the percolation rate were 1.19% and 1.09%, respectively. Conclusion The percutaneous absorption of terbinafine hydrochloride cream was very low between two products without significant difference. The penetration absorbency through Tibet minipig skins of certain enterprise cream is similar to GlaxoSmithKline china product. The most of the main components of terbinafine hydrochloride cream remain in the surface of the skins, only a few through the skin barrier. It was more suited to local cure.
出处
《实验动物与比较医学》
CAS
2013年第1期64-68,共5页
Laboratory Animal and Comparative Medicine
关键词
盐酸特比萘芬
乳膏
透皮吸收
西藏小型猪
离体
Terbinafine hydrochloride
Cream
Percutaneous absorption
Tibet minipig
in vitro
