摘要
目的 :研制阿昔洛韦凝胶。方法 :用卡波姆 940作凝胶基质 ,制备阿昔洛韦凝胶 ,建立酸碱度、卫生学、含量测定等质控方法 ,进行刺激性试验 ,光照试验 ,高速离心试验 ,耐热耐寒试验和自然室温留样考察。结果 :pH值 6.5～ 7.0 ,卫生学检查符合规定 ,含量测定平均回收率 10 0 .2 %～ 10 0 .4% ,RSD <0 .75% (n =5) ,且凝胶稳定无变化 ,无刺激性。结论 :制备该凝胶工艺简单 ,所得制剂质量可控 ,性质稳定 。
OBJECTIVE To prepare acyclovir gel.METHODS Carbopol-940 was used as the gel base.Test methods for alkalinity, hygiene, and assay were established, stability tests were conducted.RESULTS The pH value was 6.5 ～ 7.0 , and it was up to the standard of hygienic tes t. In the test of content, the average rate of recovery was 100.2% ～ 100.4% ,and RSD< 0.75% (n=5). No changes of stability and irritability had be en found. CONCLUSIONS The gel can be easily prepared by the above-stated way. The quality can be cont rolled and the stability can be maintained. The gel is a useful medicine for cli nics.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2003年第8期455-457,共3页
Chinese Journal of Hospital Pharmacy
