摘要
探讨早期联合用药对矽尘致大鼠肺纤维化的影响。 [方法 ]采用SD大鼠 ,低剂量石英粉尘非暴露式气管注入染尘 (2 0mg/鼠 )后 3d,在病变早期阶段开始给药 ,分别治疗 2个月和 5个月。疗效指标为肺湿重、肺胶元含量、肺总脂含量及肺内矽性病变分级。 [结果 ]以肺湿重、肺胶元含量、肺总脂为依据的综合疗效指标显示 ,各用药组都显著低于染尘对照组。肺内矽性病变分级亦有相应的差异。 [结论 ]早期联合用药对大鼠肺纤维化有一定阻断作用 ,其疗效优于各单独用药组。
Objective] The effects of compositions combined of two different anti silicosis medicines on experimental silicosis at early stage were investigated. [Method] SD rats were used to reproduce the model of experimental silicosis. 3 days after intratracheal instillation of quartz dust rats were treated with 4 single drugs and 3 compostitions respectively for 2 or 5 months. The comprehensive evaluation indexes were set up on the basis of fresh lung weight,collagen content and total lipid for curative effect assessment. The lung histological examination was conducted as well. [Results] The results showed that the comprehensive evaluation index in all the groups treated with single drugs and compositions were less than that in control group untreated,and this index in groups treated with compositions were less than that in groups treated with single drugs. [Conclusion] The curative effects of compositions on experimental silicosis at early stage were more efficient than those of related drugs used in single.
基金
国家"九五"攻关课题!"矽肺治疗措施及效果评价研究"的分课题 (96 90 6 0 4 1 0 )
