摘要
为探讨矽肺治疗措施及其效果评价，进行了汉防己甲素（简称汉甲）和羟基磷酸哌喹（简称羟哌）、汉甲和克矽平、柠檬酸铝（简称柠铝）和羟哌３种联合用药方案和采用大容量肺灌洗治疗矽肺的临床研究。结果表明，３种联合用药治疗与对照组比较均显示明显疗效８，呼吸系统症状的有效率达５５．７％～６６．０％，Ｘ线胸片好转率为５．５％～１１．８％（对照组没有好转病例）。在高暴露粉尘组病变进展快的病例，Ｘ线胸片的好转率达１８％～３６％；而对照组Ｘ线胸片病变显示进展的病例达３０％～６７％，明显高于治疗组的（３．３％～１３．３％）。大容量肺灌洗具有改善呼吸系统症状的作用，但Ｘ线未见明显疗效。结果提示，联合用药对矽肺病变的进展有明显抑制作用。
Poly-2-vinylpyridine-nitrogeneoxide(PVNO),bis-benzylisoquinoline(tetrandrine,TD),quinolylpiperazinehydroxylposphate(QOHP),aluminiumcitrate(ALC)andmasivewholelunglavagewereusedforthetreatmentofsilicoticpatients.540patientswithsilicosisweredividedintotreatedgroup(355)andcontrolgroup(185).Thetreatedgroupwassubdividedinto4subgroupsbasedondiferentcombinationofthedrugs,TD+QOHP,TD+PVNO,QOHP+ALCaswelaslavage.Theclinicaleficacywasevaluatedbyclinicalsymptoms:lungfunction,chestX-rayfilmandlaboratoryex-aminations.Theresultshowedthatapparentrespiratorysymptomaticimprovementwasseenin55.7%～60.0%ofthedrugtreatedgroups,significantlyhigherthancontrol.Therateofcomplicationwithin-fectionwasobviouslydecreased.TherateofimprovementinX-rayfilmswas5.5%～11.8%intreatedgroupswhereasnocaseincontrolpresentedimprovedX-rayfilm.Patientsexposedtohighlevelofdustsshowedabout18.0%～36.0%ofimprovmentinX-rayfilm,while30.0%～67.0%ofthepatientsincontrolshowedprogresioninX-rayfilms,significantlyhigherthantreatedgroups(3.3%～13.3%).Therespiratorysymptomswerealsoimprovedinmasivewholelunglavagetreatmentbutnoimprove-mentfoundinX-rayfilms.Itisconcludedthatadministrationofcombinationofthedrugsshowedobvi-ousinhibitionontheprocessoffibrosisformationandimprovementofclinicalsymptoms,andlowersideefectthanTDdrugalone.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1996年第3期130-134,共5页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
"八五"国家科技攻关基金
关键词
矽肺
汉防己甲素
羟基磷酸哌喹
克矽平
SilicosisTetrandrineQuinolylpiperazinehydroxylPhosphateAluminiumcitrate
