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肝纤维化形成的机制——信号转导通路TGF-β/smad的作用概论 被引量：8

The mechanism in formation of hepatic fibrosis
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摘要 肝纤维化是各种慢性肝病的共同病理基础,其发生与各种致病因子、炎性因子以及细胞因子等作用有关。转化生长因子-β1(transforming growth factor beta 1,TGF-β1)是TGF—β超家族的主要成员,能抑制肝细胞、内皮细胞、上皮细胞的增殖,诱导细胞外基质的形成。Smads介导TGF-β超家族受体到核基因的信号传递,smad4为其通用型smad蛋白,为TGF-β信号传递通路所必须的下游中介分子。本文主要就目前研究的热点TGF-β/smad信号转导通路在肝纤维化形成、发展中的作用进行综述。
作者 廖丹 江建宁
机构地区 广西医科大学第一附属医院传染科
出处 《国外医学（流行病学．传染病学分册）》 2004年第3期170-172,共3页 Epidemiology Lemology Foreign Medical Sciences
关键词 肝纤维化 形成机制 转化生长因子-Β1 细胞外基质 肝星形细胞活化 细胞因子
分类号 R575.2 [医药卫生—消化系统]
  • 相关文献

参考文献17

  • 1Gressner AM.transdifferentiation of hepatic stellate cell(Ito cell) to myofibroblasts key event in hepatic fibrogenesis . Kieney Int, 1996,49(54):s39.
  • 2周俊英,李兵顺,刘金星.肝纤维化的发生机制[J].河北医科大学学报,2002,23(1):50-52. 被引量：4
  • 3Raftery LA,Twombly V,Wharton K,et al. Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics,1995,139(1): 241-254.
  • 4Sekelsky JJ, Newfeld SJ, Raftery LA, et al. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics, 1995,139(3): 1347-1358.
  • 5Savage C, Das P, Finelli AL, et al. Caenorhabditis elegans genes sma-2,sma-3,and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc Natl Acad Sci USA, 1996,93(2):790-794.
  • 6Derynck R, Gelbart WM, Harland RN, et al. Nomenclature: vertebrate mediators of TGF-beta family signals. Cell, 1996,87(2): 173.
  • 7Heldin CH, Miyazono K, Ten Dijke P. TGF-beta signaling from cell membrane to nucleus through SMAD proteins. Nature, 1997(39096659):465-471.
  • 8Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science, 1996, 271 (5247):350-353.
  • 9Yakicier MC,Irmak MB,Romano A,et al. Smad2 and Smad4 gene mutatiors in hepatocellular carcinoma. Oncogene, 1999,18(34) :4879-4883.
  • 10Dooley S, Delvoux B,Lahme B,et al. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology, 2000, 31 (5): 1094-1096.

二级参考文献14

  • 1胡斌,龚鹏飞,倪若愚,罗端德.肝炎肝硬化及慢性肝炎患者血清血小板源生长因子水平的改变[J].中华传染病杂志,1996,14(3):172-173. 被引量：2
  • 2Whitman M.Smads and early developmental signaling by the TGFβsuperfamily[].Genes and Development.1998
  • 3Lee DK,Park SH,Yi Y,et al.The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis[].Genes and Development.2001
  • 4Roulot D,Sevcsik AM,Coste T,et al.Role of transforming growth factor beta type Ⅱ receptor in hepatic fibrosis:studies of human chronic hepatitis C and experimental fibrosis in rats[].Hepatology.1999
  • 5Schnabl B,Kweon YO,Frederick JP,et al.The role of Smad3 in mediating mouse hepatic stellate cell activation[].Hepatology.2001
  • 6Zhang W,Ou J,Inagaki Y,et al.Synergistic cooperation between Spl and Smad3/Smad4 mediates transforming growth factor betal stimulation of alpha 2 ( Ⅰ)-collagen(COL1A2) transcription[].Journal of Biological Chemistry.2000
  • 7Correia JJ,Chacko BM,Lam SS,et al.Sedimentation studies reveal a direct role of phosphorylation in Smad3:Smad4 homo-and hetero-trimerization[].Biochemical Journal.2001
  • 8Takiya S,Tagaya T,Takahashi K,et al.Role of transforming growth factor beta Ⅰ on hepatic regeneration and apoptosis in liver diseases[].Journal of Clinical Pathology.1995
  • 9Bedossa P,Peltier E,Terris B,et al.Transforming growth factor-beta l(TGF-beta 1)and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers[].Hepatology.1995
  • 10刘一平,邓继先.SMAD蛋白家族:一类新的细胞内信号传导蛋白[J].生物技术通讯,1998,9(3):198-204. 被引量：2

共引文献17

同被引文献106

引证文献8

二级引证文献52

国外医学（流行病学．传染病学分册）
2004年 第3期

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