摘要
目的 观察汉防己甲素治疗尘肺疗效及对免疫功能的影响。方法71例尘肺患者随机分为治疗组（36例）和对照组（35例），治疗组服用汉防己甲素，对照组服用矽肺宁，观察治疗前后和两组间症状变化及治疗前后免疫功能的变化。结果与治疗前和对照组比较，治疗组用药后咳嗽、胸痛、气紧积分减少，差异有统计学意义（P〈0．05）。治疗组症状改善积分下降百分率为69．35％，对照组为50．00％，两组比较，差异有统计学意义（P〈0．05）。治疗组上呼吸道感染发生人数和肺部感染人数分别为13例和2例，发生率分别为36．11％和5．55％。对照组上呼吸道感染发生人数和肺部感染人数分别为22例和4例，发生率分别为57．14％和28．57％。，两组比较，差异有统计学意义（P〈0．05）。与治疗前比较，治疗组治疗后CD4明显上升，CD8明显下降，CD4／CD8明显上升，差异有统计学意义（尸〈O．05）。治疗后，与对照组比较，治疗组CD4明显上升，CD8明显下降，CD4／CD8明显上升，差异有统计学意义（尸〈O．05）。治疗前后，两组间免疫球蛋白（IgG、IgA、IgM）比较，差异无统计学意义（P〉0．05）。结论汉防己甲素有较好的改善尘肺患者临床症状的效果，对细胞免疫功能有一定的调节作用，其症状改善、上呼吸道感染发生率和肺部感染率的减少，可能与机体细胞免疫功能增强有关。
Objective To observe the curative effect of HanFangJiaSu on pneumoconiosis. Method 71 patients with silicosis were divided into trial group and control group at random. The treating group （36 pa- tients） was treated 90 days with HanFangJiaSu and The contrl group （35 patients） was treated 90 days with XiFeiNing. The silicosis with cough,chest complaint, dyspnoed and immune modulation were observed before treating and after treating. The effect was compared between the two groups. Result To compared with the group before treatment and the control group, the symptoms score of cough, chest complaint and dyspnoed in treated group was significantly decreased after treatment（P〈0.05）. The rate was decreased by 69.35% in treated group and 50.00% in controls, which showed the treatment in both groups was effeetive. The rate in treated group was significantly decreased more than in controls （P〈0.05）. There were 13 cases with respiratory toact in- fection and 2 cases with lung infection in treated group of which percentage were 36.11% and 5.55%, while 22 cases and 4 cases in control group of which percentage were 57.14% and 28.57%. There was a significant dif- ference between the two groups （/）〈0.05）. To compared with the group before treatment, the quantity of CD4 in blood was obviously increased, while CD8 was obviously decreased, which showed a significant increase of CD4/ CD~ （P〈0.05）. To compared with control group, the quantity of CD4 in treated group was obviously increased, while CD8 was obviously decreased, which also showed a significant increase of CDJCD8 （/）〈0.05）. There was no significant difference with the concentration of immune globulin （IgG, IgA, IgM） between the groups before
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2011年第10期783-785,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
