摘要
Ginseng has long been used as a tonic and agent for prolonging life span in chinese traditional medicine ．Using morden technology ginsenoside Rgl and Rbl were proved to be main active principles of ginseng． Both conpounds showed the same effect in improving learning and memory，increasing Bmax of M-cholinergic receptors and accelerating cerebral protein and acetylcholine biosynthesis． However， Rgl but not Rbl had immunoregulatory action in aged rats and anti-osteoporosis effect in ovariectomized rats as well as enhanced basic synaptic transmission and magnitude of LTP induced by HFS ．On the other hand， Rbl had anti-stress effects in antagonizing acute,chronic and repeated stress induced reduction of sexual behaviour and decrease of plasma andogen or estrogen．Rgl showed no such effect even aggravate stress induced damage．Rhl possessed antioxidant activity and prolong survival time of mice in cold(－℃10 )condition．There was no any anti-cold effect with Rgl .These diference of biological activities between Rgl and Rbl may be arributed to their structures containing different number of glucoses．
Ginseng has long been used as a tonic and agent for prolonging life span in chinese traditional medicine ．Using morden technology ginsenoside Rgl and Rbl were proved to be main active principles of ginseng． Both conpounds showed the same effect in improving learning and memory，increasing Bmax of M-cholinergic receptors and accelerating cerebral protein and acetylcholine biosynthesis． However， Rgl but not Rbl had immunoregulatory action in aged rats and anti-osteoporosis effect in ovariectomized rats as well as enhanced basic synaptic transmission and magnitude of LTP induced by HFS ．On the other hand， Rbl had anti-stress effects in antagonizing acute,chronic and repeated stress induced reduction of sexual behaviour and decrease of plasma andogen or estrogen．Rgl showed no such effect even aggravate stress induced damage．Rhl possessed antioxidant activity and prolong survival time of mice in cold(－℃10 )condition．There was no any anti-cold effect with Rgl .These diference of biological activities between Rgl and Rbl may be arributed to their structures containing different number of glucoses．
出处
《基础医学与临床》
CSCD
2000年第5期4-6,共3页
Basic and Clinical Medicine
基金
国家重点基础研究规划项目
关键词
人参皂甙
RG1
RB1
药理作用
ginsenoside Rgl and Rb1 learning and memory； antioxidant and antistress activity； M-cholinergic receptors
