摘要
目的:确定中药醒神方2种主要成分的最佳用量。方法:应用均匀设计处理手段与药效学实验(戊巴比妥催眠实验、小鼠转棒疲劳实验)相结合的方法对中药醒神方中各味药用量进行筛选。结果:醒神方中人参茎叶总皂苷、绿茶提取物的最佳量分别为14.192、.86mg/20g,能明显减少戊巴比妥所致小鼠睡眠时间,延长小鼠转棒耐力时间。验证实验证明,中药醒神方有对抗中枢及身躯体疲劳的作用。结论:应用均匀设计、数理统计与药效学分析相结合的方法确定复方药用量的方法是可行的。
Object： To define the optimum dosage of two main ingredients in XingShengFang. Method： Uniformdesign method combined with pharmacyodynamics（hypnogenetic effects of sodium pentobarbital and roating bar tolerance observed in rats was used in the study）was used to screening the optimnm dose of ingredients in XingShengFang. Result： The optimnm dosage of Ginsenoside was 2.86mg/20g and the extracts from green tea, 14.19mg/20g. They could notably prolong the persisting time on the roating bar and shorten the sleeping time caused by sodium pentobarbital. Conclusion： It would be possible to use uniform-design combined with pharmacyodynamics method in defining the optimal dosage of ingredients in XingShenFang.
出处
《中国实验方剂学杂志》
CAS
2006年第1期25-27,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
全军医药卫生科研基金资助课题(No.01Z053)
关键词
均匀设计
醒神方剂
抗疲劳
uniform-design method
XingShenFang
anti-fatigue
