摘要
目的 :探讨胃印戒细胞癌的组化、免疫组化特性与超微结构特征的相关性 ,为胃印戒细胞癌发生发展和诊断提供依据。方法 :对 5 3例胃印戒细胞癌的病理标本进行AB -PAS组化染色及CEA免疫组化检测 ,同时进行电镜超微结构观察。结果 :癌细胞呈现三种形态 :单核细胞样、浆细胞样及印戒细胞样。分泌三种粘液 :肠型酸性粘液、胃型中性粘液和混合型粘液 ,并可同时见于癌组织的不同区域中。本组胃印戒细胞癌组织中CEA均呈强阳性。癌细胞超微结构分为三种形态 :暗细胞型、粘液型、微囊型。结论 :印戒细胞癌的主要特征为CEA性粘液分化 ,印戒细胞癌的三种形态反映CEA性粘液发生、演变至终末期发展的全过程 ;CEA肿瘤特异性表达。
Objective:To observe the ultrastructural and immunohistochemical features of the gastric signetring cell(SRC) carcinoma.Methods:Immunohistochemical and mucin histochemical staining and electron microscope were used to examine 53 specimens of the signetring cell carcinoma of stomach.Results:The 53 cases of gastric SRC carcinoma could be divided into three types(monocytoid,plasmocytoid and signetringlike type)by their morphological features and three types could be seen in one case.There were three types of mucin(acid,neutral and mixed mucin)after mucin staining.CEA in all of 53 cases were positive after immunohistochemical detection.Ultrastructure of SRC could be classified into three types.They were infantile,mucous and microcystic type and their differentiation were from low to higher.The mucin secretion was biphasic and reversible.Conclusion:The expression feature of mucin of SRC carcinoma,which might originate from the stem cells of gastric,is closely related to CEA and ultrastructure changes.The ultrastructural changes of SRC mainly reflect multidirection differentiation and immature structure and function in the cells.
出处
《西北国防医学杂志》
CAS
2000年第2期137-138,共2页
Medical Journal of National Defending Forces in Northwest China
关键词
胃印戒细胞癌
超微结构
免疫组织化学
Gastric signet-ring cell carcinoma
Immunohistochemistry
Ultrastructure
