摘要
目的:探讨CD44v6和PTEN在胃印戒细胞癌组织中的表达与临床病理特征及预后之间的关系。方法:应用免疫组织化学SP二步法,检测73例胃印戒细胞癌组织中CD44v6及PTEN的表达,分析CD44v6、PTEN与胃印戒细胞癌浸润深度、淋巴结转移、器官转移、临床分期和三年生存率的关系。结果:73例胃印戒细胞癌组织中CD44v6阳性率为78.1%(57/73),PTEN阳性表达率为34.2%(25/73),PTEN表达与器官转移、临床分期有差异(P<0.05),CD44v6、PTEN表达均与胃印戒细胞癌浸润深度、淋巴结转移有差异(P<0.05)。两者之间Spearman等级表达呈负相关(r=-0.214,P<0.05);Kaplan-Meier生存分析显示PTEN阴性组三年生存率16.1%显著低于PTEN阳性组66.9%(P<0.01)。结论:进行CD44v6和PTEN免疫组织化学检测对评估胃印戒细胞癌的预后具有一定意义。
Objective： To study the expression of CD44v6 and PTEN in gastric signet ring cell carcinoma and their relation to the clinieopathological features and prognosis. Methods： CD44v6 and PTEN protein expression in 73 cases of gastric signet ring cell carcinoma were examined by using SP immunohistochemical staining. CD44v6 and PTEN expression were analyzed together with their relation to depth of invasion and lymph node metastasis, distant metastasis, clinical stage and three-year survival. Results： The positive rate of CD44v6 was 78.1%（57/73）, and the PTEN was 34.2%（25/73）. The protein expression of CD44v6 and PTEN was related with the depth of invasion and lymph node metastasis （P〈0.05）, and PTEN was also related with the distant metastasis and TNM stage （P〈0.05）. The expression of PTEN was negatively correlated to that of CD44v6 （r=-0.214, P〈0.05）; Kaplan-Meier survival curves show that the 3-year survival rate was significantly higher in PTEN-positive patients than that in PTEN-negative patients （66.9% VS 16.1% P〈0.01）. Conclusions： It is significant for prognosis to examine the CD44v6 and PTEN by using immunohistochemical staining at the same time.
出处
《现代生物医学进展》
CAS
2009年第4期706-708,共3页
Progress in Modern Biomedicine
