摘要
目的分析对比不同剂量奥曲肽治疗食管胃静脉曲张破裂出血的有效性和安全性。方法以2010年1月～2011年1月收治的76例食管胃静脉曲张破裂出血的患者为试验对象。按照随机数字表将患者分为两组,常规剂量组38例每日给予600mg,加倍剂量组每日1200mg,观察比较治疗效果。结果加倍剂量组患者止血时间为(16.24±2.97)h,明显高于常规剂量组患者止血时间(23.99±2.62)h;加倍剂量组患者48h止血率为37(89.47%),明显高于常规剂量组患者48h止血率29(76.32%);加倍剂量组患者再出血率为1(2.63%),明显低于常规剂量组患者再出血率6(15.79%)。组间比较差异显著,P<0.05,差异有统计学意义。结论在食管胃静脉曲张破裂出血治疗中每日给予1200mg奥曲肽可以取得较好的效果。
Objective To analyze the efficacy and safety of comparing different doses of octreotide treatment of esophageal and gastric variceal bleeding. Methods From January 2010 to January 2011 , 76 cases in our hospital of esophageal and gastric variceal bleeding as experimental subjects. All cases were divided into two groups by random number table, 38 cases were the conventional group who wer given Octreotide 600mg a day, doubling dose group 1200mg. Treatment effect was observed. Results Doubling dose group of patients with hemostatic time was （16.24±2.97 ） h, significantly higher than that of conventional dose group of patients with bleeding time （ 23.99±2.62 ） H; double dose group of patients 48 hours hemostatic rate was 37 （89.47%）, was significantly higher than that of conventional dose group of patients 48 hours hemostatic rate was 29 （76.32%）; the doubling dose group of patients with bleeding rate of 1 （2.63%）, was significantly lower than that of conventional dose group of patients with rebleeding rate was 6 （15.79%）. The difference between groups was significant, P〈0.05, the difference was statistically significant. Conclusion The patients of esophageal and gastric variceal bleeding were given 1200mg octreotide each day which can achieve better effects.
出处
《当代医学》
2012年第32期37-38,共2页
Contemporary Medicine
关键词
静脉曲张
出血
奥曲肽
Varicose veins
Bleeding
Octreotide
