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国产生长抑素与善宁治疗食管-胃底静脉曲张破裂出血的对比研究 被引量:2

Comparision of Sandostatin with Homemade Somatostatin in the Treatment of Esophageal Variceal Bleeding
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摘要 目的:对国产生长抑素和善宁治疗食道-胃静脉曲张破裂出血(EGVB)的疗效。方法:57例肝硬化EGVB病人随机分成两组。治疗组予国产生长抑素先予250μg iv后250μg/h持续静脉泵入5 d,对照组予善宁先予0.1 mgiv后25μg/h持续静脉泵入5 d。结果:治疗组和对照组的止血时间7、2 h止血率、再出血率、病死率分别80.64%、(12±1.5)h、25.81%、6.45%,84.61%(、12±8.1)h、23.08%、3.85%。结论:国产生长抑素和善宁在治疗肝硬化EGVB病人疗效相似。 Objective: To compare the efficacy of sandostatin and homemade somatostatin in the treatment of esophageal variceal bleeding due to portal hypertension. Methods:A total of 57 patients with esophageal variceal bleeding due to hepatic cirrhosis were randomly divided into two groups. In treatment group,homemade somatostatin was infused by 250 μg bolus then 250μg/h continuous intravenous for 5 days. In control group, sandostatin was infused by 0. 1 mg bolus then 25 μg/h continuous intravenous for 5 days. Results : Hemostasis rate, hemostasis time, rebleeding rate,mortality rate in 72 hours were 80.64% ,(12±1.5)h,25.81%,6. 45%,84.61% ,(12±8.1) h,23.08% ,3.85% ,respectively in treatment group and control group. Conclusion:The efficacy of homemade somatostatin is similar to that of sandostatin in treatment of esophageal variceal bleeding due to hepatic cirrhosis.
出处 《实用临床医学(江西)》 CAS 2006年第6期44-45,共2页 Practical Clinical Medicine
关键词 生长抑素 善宁 食管-胃静脉曲张破裂出血 门脉高压症 肝硬化 somatostatin sandostatin esophageal variceai bleeding portal hypertension hapertic cirrhosis
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  • 1吴云林.食管曲张静脉穿刺测压和药物降压研究[J].新消化病学杂志,1996,4(10):575-576. 被引量:5
  • 2WONG T,WILKINSON ML.Somatostatin Plus Isosorbide Mononitrate Versus Somatostatin in the Control of Acute Gastro-oesophageal Variceal Bleeding:A Double Blind,Randomised,Placebo Controlled Trial[J].Gastrointest Endosc,2001,54(2):275-276.
  • 3BURROUGHS AK.Assessment of Value of Consensus Definitions in Acute Variceal Bleeding[J].Lancet,2001,357:1 147-1 148.

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