摘要
从载体材料的种类、黏附作用的机制和对材料的修饰等方面,分析及探讨影响微球在鼻腔黏膜表面黏附性能的载体因素。制备鼻腔微球的过程中,所选用生物黏附性材料的种类、相对分子质量大小、制剂pH值以及对材料的修饰均对微球制剂的黏附性有一定的影响,为研究鼻腔给药微球提供了思路。
Intranasal microspheres have gained increased interest in recent years.The mucoadhesive properties between microspheres and nasal mucosa via intranasal administration were remarkable affected by factors such as species of polymer materials,molecular weight,pH and modifications.During the process of the preperartion,the mucoadhesion of microspheres has a great relationship between the above facrors.Thus this review focuses on how the above factors affecting the mucoadhesion of microspheres via intranasal administration.
出处
《广东药学院学报》
CAS
2012年第4期451-455,共5页
Academic Journal of Guangdong College of Pharmacy
基金
广东省科技计划项目(2007B030502003)
关键词
微球
鼻腔给药
载体材料
黏附性
microspheres
intranasal administration
carriers
mucoadhesion
