摘要
近年来已有多种药物实现了以壳聚糖微球作为缓控释载体,并在生物医学领域展现出良好的应用前景,成为缓控释剂型研究的热点之一。目前对壳聚糖微球释放机制的研究进展落后于壳聚糖载药微球制备与应用的研究进展,而加强壳聚糖载药微球药物释放机制的研究,有利于更好地了解药物的释放行为和释放影响因素,并对深入研究壳聚糖缓释载药体系的制备与应用具有重要意义。主要从壳聚糖微球的药物释放机制、药物释放行为描述、药物释放影响因素等方面进行了综述。
Variety of drugs-loaded chitosan microspheres have been used as sustained release carrier in recent years,which has shown a good prospect in biomedical field.Therefore,chitosan microspheres have been one of the research hotspots in controlled release drug delivery system.Nowadays the research in releasing mechanism of drug-loaded chitosan microspheres lags obviously behind the research in preparation and application.Moreover further research in drug releasing mechanism of chitosan microspheres is beneficial to understanding of drug releasing behavior and to analyzing the influencing factors,and the further research is also important to the preparation and application of chitosan microspheres for drug sustained-release.The present paper comprehensively introduces the drug releasing mechanism,describes drug release behavior and analyzes the main releasing releasing influencing factors on the releasing process.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2011年第4期843-846,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金青年基金资助项目(51003008)
关键词
壳聚糖
微球
缓释
药物释放
机制
Chitosan
Microspheres
Sustained release
Drug releasing
Mechanism
