摘要
目的探讨人参皂苷Rg1的鼻腔吸收、冰片的促进吸收作用及对鼻腔纤毛的毒性。方法采用在体蟾蜍上腭法研究药物对纤毛运动的影响;采用大鼠在体鼻腔循环法研究人参皂苷Rg1鼻腔吸收的特性及冰片对其吸收的影响;采用扫描电镜观察人参皂苷Rg1及冰片对大鼠鼻腔纤毛的急性毒性。结果循环液中人参皂苷Rg1的含量为100,250,500 mg.L-1时,鼻腔的吸收速度常数分别为0.000 30,0.000 40和0.000 7 min-1。循环液中含有10 g.L-1,2%和3%的冰片时,对250 mg.L-1的人参皂苷Rg1吸收速度常数分别为0.001 9,0.001 2和0.001 3 min-1。结论人参皂苷Rg1能通过鼻腔黏膜吸收,对纤毛无毒,10 g.L-1的冰片对其吸收有促进作用。
OBJECTIVE To investigate the nasal absorption of ginsenoside Rg1 and the absorption enhaneen effect of borneol. METHODS THe effect of ginsenoside Rgl and borneol on cililary movement were evaluated by in situ toad palate model. Nasal circulatory perfusion test in vivo was employed to investigate the characteristics of nasal mucosa absorption ginsenoside Rgl in rats. The election mieroscope scanning technique was used to evaluate the nasal eiliotoxicity of ginsenoside Rg1 and borneol on the nasal mucosas of the rats. RESULTS When the concentrations of ginsenoside Rg1 were 100,250,500mg·L^-1, respectively, the corresponding values of the absorption rate were 0. 000 30, 0.000 40 and 0. 000 7 min^-1. However, when the concentration of ginsenoside Rgl was 250 mg·L^-1 in circulation liquid, the absorption rates were 0.0019,0.0012 and 0.0013 min^-1 with the aid of borneol of 10, 20 and 30 g·L^-1 .CONCLUSION Ginsenoside Rgl can be absorted through the nasal mucous and borneol can enhance the absorption. The Ginsenoside Rgl spray has no daraage to the nasal mueosas of rats.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第4期261-264,共4页
Chinese Pharmaceutical Journal
关键词
人参皂苷RG1
冰片
鼻腔吸收
纤毛毒性
ginsenoside Rg1
borneol
nasal absorption
nasal ciliotoxicity
