摘要鼻腔给药系统(nasal drug delivery system,NDDS)是指在鼻腔内使用,经鼻粘膜吸收而发挥局部或全身治疗作用的制剂。鼻腔给药历史悠久,但过去大多用于治疗鼻炎、鼻塞等届部疾病,起局部消炎、收敛、杀菌等作用。近年来随着新辅粒和治疗新技术的应用,发挥全身治疗作用的鼻腔给药制剂酏研究越来越受到人们的广泛关注。
8Ahn EN, Kim SK, Shim CK.Proliposomes as an intranasal dosage form for the sustained delivery of propranolo[J]. J Control Release, 1995, 34:203.
9Maitani Y, Asano S, Takahashi S, et al. Permeability of insulin entrapped in liposome through the nasal mucosa of rabbits [J]. Chem Pharm Bull Tokyo, 1992, 40(6): 1569.
10Morimoto K et al. J Pharm Pharmacol 1985, 37(2): 134.
二级参考文献4
1王静清,临床耳鼻咽喉科杂志,1994年,8卷,20页
2Wang J Q,Chin Med J,1991年,104卷,60页
3G. S. M. J. E. Duchateau,B. Rademaker. Abstracts of Dutch doctoral theses[J] 1987,Pharmaceutisch Weekblad Scientific Edition(6):326~329
8WU Jinhui , DING Dawei, REN Guoyan, et al. Sustained delivery of endostatin improves the efficacy of therapy in lewis lung cancer model[J].Journal of Controlled Release, 2009, 134 : 91 - 97.
9CHEUNG R Y, RAUTH A M,RONALDSON P T, et al. In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin [ J ]. European Journal of Pharmaceutics and Biophamaceuties, 2006, 62 ; 321 - 331.
10LIU Baorui, YANG Mi,LI Rutian, et al. The antitumor effect of novel docetaxel-loaded thermosensitive micelles [ J ]. European Journal of Pharmaceutics and Biophaceutics, 2008, 69:527 - 534.