摘要
目的探讨腹泻型肠易激综合征(IBS)与幽门螺杆菌(H.pylori)感染之间的关系。方法将96例腹泻型IBS患者与92例健康体检者对照,采用14C-尿素呼气试验法及快速尿素酶法检测H.pylori感染情况,并根据检测结果将56例H.pylori阳性的腹泻型IBS患者分为观察组和对照组,两组同时给予匹维溴胺、蒙脱石治疗4周,观察组同时加用抗H.pylori治疗2周,观察其疗效。结果腹泻型IBS组H.pylori感染率为58.3%,健康体检组H.pylori感染率为51.1%,两组H.pylori感染率比较,差异无统计学意义(P>0.05)。加用抗H.pylori治疗的观察组显效11例,有效13例,无效6例;对照组显效10例,有效11例,无效5例,两组疗效间差异无统计学意义(u=-0.1232,P>0.05)。结论腹泻型IBS与H.pylori感染无关联。
Objective To investigate on the relationship between diarrhea types of irritable bowel syndrome（IBS）and helicobacter pylori（H.pylori）infection.Methods Totally 96 patients with diarrhea-predominant IBS and 92 healthy controls were enrolled in this study.H.pylori infection was detected using 14C-urea breath test and fast urease method;based on the results,56 H.pylori-positive patients with diarrhea-predominant IBS were randomly divided into observation and control groups.Both groups were treated with pinaverium bromide and smecta for 4 weeks,and patients in the observeration group also received anti-H.pylori for 2 weeks.Results The H.pylori infection rate was 58.3% in patients with diarrhea-predominant IBS and 51.1% in healthy controls（P0.05）.The total effective rate was 80.0% in the observation group and 80.8% in the control group,which also showed no significant difference（u=-0.1232,P0.05）.Conclusion Diarrhea-predominant IBS shows no correlation with H.pylori infection.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第17期1912-1913,共2页
Chinese General Practice
关键词
螺杆菌
幽门
肠易激综合征
革兰阴性菌感染
Helicobacter pylori
Irritable bowel syndrome
Gram-negative bacterial infections
