摘要
目的 分析匹维溴铵联合益生菌治疗肠易激综合征的临床疗效。方法 156例腹泻型肠易激综合征患者随机分为观察组和对照组,对照组口服匹维溴铵片,观察组在服用匹维溴铵的基础上,口服双歧三联活菌制剂,两组疗程均为4周。治疗结束后评价两组的临床疗效。结果 观察组和对照组总有效率分别为85.9%和70.5%,观察组临床疗效显著优于对照组（χ2=8.557,P〈0.05）;治疗后观察组肛门直肠收缩压较对照组显著降低（t=4.432,P〈0.01）,而静息压和舒张压差异无统计学意义（t=0.812、0.142,均P〉0.05）;治疗后观察组的初始感觉阈值、排便阈值和疼痛阈值均显著高于对照组（t=3.440、4.671、3.697,均P〈0.01）。结论 匹维溴铵联合益生菌治疗肠易激综合征的临床疗效显著,显著改善患者的肛门直肠动力和内脏敏感性。
Objective To investigate clinical effect of pinaverium bromide combined with probiotics in the treatment of patients with irritable bowel syndrome（IBS）.Methods 156 patients with IBS were randomly divided into observation group and control group.Cases in control group received pinaverium bromide tablets,and cases in observation group received bifid triple viable capsule plus pinaverium bromide tablets.Duration of treatment was 4 weeks in both groups.Clinical efficacy was evaluated after treatment.Results Total effective rates of observation group and control group were respectively 85.9% and 70.5%.Total effective rate of observation group was significantly better than that of control group（χ2=8.557,P〈0.05）.The systolic pressure of anorectum was significantly lower than that of control group after treatment（t=4.432,P〈0.01）,but resting pressure and diastolic pressure were not significantly different after treatment（t=0.812,0.142,all P〉0.05）.First sensation volume,defecating sensation volume and pain volume in observation group were significantly lower than those in control group（t=3.440,4.671,3.697,all P〈0.01）. Conclusion Treatment of IBS with pinaverium bromide combined with probiotics is effective,and it can improve the anorectal dynamic and isceral sensitivity in patients with IBS.
出处
《中国基层医药》
CAS
2013年第1期34-36,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
匹维溴铵
益生菌
腹泻
肠易激综合征
Pinaverium bromide
Probiotics
Diarrhea
Irritable bowel syndrome
