摘要
目的应用选择性肠道钙离子拮抗剂(匹维溴胺)治疗肠易激综合征(Irritable Bowel Syndmme,IBS),观察临床疗效以及其对回盲部肥大细胞的影响,探讨其治疗 IBS 的可能机制。方法符合人选标准的 IBS 患者80例,应用肠道钙离子拮抗剂治疗前后观察疗效以及检测回盲部脱颗粒肥大细胞的数目变化。结果应用选择性肠道钙离子拮抗剂治疗前后回盲部脱颗粒肥大细胞数目有变化。结论应用选择性肠道钙离子拮抗剂治疗腹泻型 IBS 有效,可能抑制了肥大细胞的活化,机理有待于进一步探讨。
Objective To investigate the effect and mechanism of pinaverium bromide on irritable bowel syndrom,and to observe the effect on mast cell of ileoceam. Methods Eighty patients with IBS were questioned . To investigate the curative effect and to count the number of mast cell with degraulation after pinaverium bromide treatment. Results The number of mast cell at ileocecum changed after the treatment with selective intestinal calciam cation antlyonist. Conclusion Selective intestinal calcium cation antagonist is effective in the therapy of diarrhea type of IBS and its mechanism may involve in inhibiting the activity of mast cell. Despite our findings, it is still controversial whether mast cells play a key role in IBS. The pathophysiological mechanism of IBS should be further investigated.
出处
《临床急诊杂志》
CAS
2008年第4期228-230,共3页
Journal of Clinical Emergency
关键词
肠易激综合征
肥大细胞
匹维溴胺
Mast cell
Irritable bowel syndrome
Pinaverium bromide
