摘要
目的：探讨运用白细胞粘附分子ＬＦＡ－１单抗和血管内皮细胞粘附分子ＩＣＡＭ－１单抗防治烧伤休克、改善微循环的作用机理．方法：复制大鼠烧伤休克模型，用红细胞跟踪相关仪和电视测微仪测量微静脉血液流速、口径、流量；镜下观察细静脉白细胞粘附数，并记录动物存活时间。结果：单抗能减缓烧伤休克大鼠平均动脉压和微静脉血流速度的下降趋势，显著降低微静脉的白细胞附壁粘着数，明显延长动物的存活时间，两种单抗同时使用的效果更好．结论：运用粘附蛋白单抗能阻断白细胞与内皮细胞的粘附，减少白细胞嵌塞微静脉，达到改善烧伤休克微循环和保护组织细胞的作用．
Aim: T0 detect the effect of adhesion protein monoclonal antibody on microcirculation disorder in burn shock of wistar rats. Methods: The flow velocity and diameter of venule were measured by RBC tracking correlator and IV550 model video microscaler from burn shock models of rats. foe number of leukocytes adhered on venule wall was calculated under microscope. The animal survived time was observed. Results: LFA -- 1 and ICAM -- 1 monoclonal antibodys could attenuate the falling of mean arterial pressure, significantly reduce the number of leukocytes adhered on venule wall, obviously prolong the animals' survival time. Conclusion: Adhesion protein monoclonal antibody can decrease the number of adhered leukocytes to endothelial cells, attenuate the tether of leukocytes to venule and improve microcirculation in burn shock of rats.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
2000年第1期87-91,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广东省自然科学基金!940303
关键词
粘附蛋白
单克隆抗体
烧伤休克
微循环
adhesion protein
monoclonal antibody
burn shock
microcirculation
