摘要
目的：探讨高渗氯化钠 醋酸钠溶液对低血容量性休克改善作用的机制。方法：成年ＳＤ大鼠随机分为３ 组：７．５％ ＮａＣｌ治疗组（ＨＳ组）、５％ ＮａＣｌ＋ ３．５％ ＮａＡｃ治疗组（ＨＳＡ 组）和０．９％ ＮａＣｌ对照组（ＮＳ组）。用高倍显微电视放大技术在体观察低血容量性休克时脊斜肌细静脉白细胞附壁数，用细胞液流室离体观察白细胞 内皮细胞粘附率的变化。结果：休克后各组细静脉白细胞附壁数显著增加，ＨＳＡ 显著减少细静脉白细胞附壁数，ＨＳ可短暂减少白细胞附壁数。在不同的壁切应力作用下，ＨＳＡ 组白细胞 内皮细胞粘附率显著低于ＨＳ组和ＮＳ组，ＨＳ组白细胞与内皮细胞的粘附率与ＮＳ组比较无显著差别。结论：ＨＳＡ
Objective:To observe the effect of hypertonic NaClNaAc on adhesive feature of leukocyte in rats subjected to hemorrhagic shock.Methods:Adult SpragueDawley rats were randomly divided into three groups:5% NaCl3 5 % NaAc(HSA group),7 5% NaCl(HS group),and 0 9% NaCl(NS group).The adherence of leukocyte to endothelium in vivo and in vitro during hemorrhagic shock state were studied with high magnified microscopic TV technique and cellular flow chamber respectively.Results:It was shown that the amount of leukocyte adherent to venular wall was increased obviously during hemorrhagic shock.Resuscitation with HSA was associated with a significant reduction of adherent to white blood cells compared with HS and NS groups.The adhesive rate of leukocyte to cultured endothelium under different wall stress in HSA group was remarkably lower than in HS and NS groups.There were no differences in leukocyte adhesiveness between HS and NS groups.Conclusions:The results suggest treatment with HSA could improve adhesive feature of leukocyte in rats subjected to hemorrhagic shock.
出处
《中国危重病急救医学》
CSCD
1999年第10期599-601,共3页
Chinese Critical Care Medicine
基金
军队"九五"医药卫生科研基金
关键词
休克
低血容量性
高渗氯化钠
白细胞粘附
hemorrhagic shock
hypertonin NaClNaAc solution
leukocyte adherence
