摘要
目的 探讨细胞间粘附分子1(ICAM1) m RNA 在重型乙型肝炎肝内的表达水平及其意义。方法 用原位杂交技术检测11 例非肝病对照者,5 例慢性无症状HBsAg 携带者(AsC) 、15 例慢性乙型肝炎和30 例重型乙型肝炎患者肝内ICAM1 mRNA 原位表达。结果 非肝病者和AsC肝细胞无ICAM1 mRNA表达;重型乙型肝炎患者肝细胞ICAM1 mRNA表达明显增强,其表达水平显著高于慢性乙型肝炎。结论 ICAM1
Objective To study hepatic expression of intercellular adhesion molecule 1 (ICAM 1) mRNA and its role in the pathogenesis of severe viral hepatitis B. Methods Hepatic expression of ICMA 1 mRNA was studied in 11 individuals without liver diseases, 5 chronic asymptomatic HBsAg carriers (AsC), 15 patients with chronic hepatitis B and 30 patients with severe hepatitis B by in situ hybridization. Results No ICAM 1 mRNA expression was found in the hepatocytes on the specimens from individuals without liver diseases and AsC. Enhanced expression of ICAM 1 mRNA was observed on the hepatocytes in the patients with severe hepatitis B, and it was stronger than that in the patients with chronic hepatitis B. Conclusion ICAM 1 plays an important role in the mechanism responsible for liver necrosis in the patients with severe viral hepatitis B.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2000年第1期23-25,共3页
Chinese Journal of Infectious Diseases
