摘要
目的：探讨慢性乙型肝炎（ＣＨＢ）患者血清可溶性细胞间粘附分子１（ｓＩＣＡＭ１）水平与肝损害的关系。方法：用ＥＬＩＳＡ检测正常人、慢性无症状ＨＢｓＡｇ携带者（ＡｓＣ）和ＣＨＢ患者血清ｓＩＣＡＭ１。结果：ＣＨＢ患者血清ｓＩＣＡＭ１明显高于正常人和ＡｓＣ；ＣＨＢ患者血清ｓＩＣＡＭ１水平与其血清门冬氨酸转氨酶（ＡＳＴ）和总胆红素均呈明显正相关，与凝血酶原活动度呈明显负相关；重度ＣＨＢ患者血清ｓＩＣＡＭ１明显高于中、轻度ＣＨＢ。结论：ＣＨＢ患者血清ｓＩＣＡＭ１水平均有不同程度升高，血清ｓＩＣＡＭ１水平可作为反映ＣＨＢ患者肝损害程度的指标之一。
Objective:To study the relation between serum levels of sICAM 1 and liver damage in patients with chronic viral hepatitis B(CHB). Methods: Serum sICAM 1 of healthy persons,chronic asymtomic HBsAg carriers(AsC) and patients with CHB was measured by ELISA.Results: Serum levels of sICAM 1 in patients with CHB were significantly increased,compared with healthy persons and AsC. There were significantly positive correlation among serum levels of sICAM 1 and serum AST,total bilirubin, and significantly negative correlation between serum levels of sICAM 1 and activity of prothrombin in patients with CHB. Conclusion:Serum levels of sICAM 1 were significantly increased in patients with CHB,and may reflect the damage of liver.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第4期185-186,共2页
Chinese Journal of Immunology
