摘要
目的 探讨L－selectin(L－选择素)和ICAM－1(细胞间粘附分子－1)在乙型肝炎病毒感染造成肝功能损害过程中的作用.方法 定量检测42例乙型肝炎病人血清HBV DNA拷贝数、可溶性L－选择素(sL－selectin)、可溶性细胞间粘附分子－1(sICAM－1)及肝功能相关生化指标,并对结果进行统计分析.结果 22例DNA阴性和20例DNA阳性病人血清sL－selectin和sICAM－1水平均明显高于对照组(P＜0．05),但DNA阴性组和阳性组之间的sL－selectin和sICAM－1水平均无显著差异(P＞0．05)；DNA拷贝数与sICAM－1水平呈负相关(r＝－0．501,P＜0．05)；DNA拷贝数与肝功能损害呈负相关；42例乙肝病人的sL－selectin和sICAM－1水平均与肝功能损害呈不同程度的正相关.结论 L－selectin和ICAM－1均参与乙肝病毒感染后的肝功能损害过程,而血清中sL－selectin水平升高要早于sICAM－1.
Objective To evaluate the effect of L－selectin and ICAM－1 in liver injury of patients infected with hepatitis B virus HBV． Method The copies of HBV DNA levels of sL－seclectin sICAM－1 and liver function correlated biochemical indices in 42 patients with HBV were determined and statistically analysed． Results Significant elevation of sL－selectin and sICAM－1 levels was observed in 22 HBV DNA negative patients and 20 HBV DNA positive patients P＜0．05 but no significant difference in the levels of sL－selectin and sICAM－1 between these two groups of patients P＞0．05 The number of copies of HBV DNA was negatively correlated with sICAM－1 r＝－0．501P＜0．05 and liver injury The sL－selectin and sICAM－1 levels were positively correlated in different degress with liver injury in all 42 patients． Conclusion Both L－selectin and ICAM－1 participate in the process of liver injury in HBV infection with elevation of serum sL－selectin level earlier than that of sICAM－1．
出处
《江西医学检验》
2000年第4期193-195,共3页
Jiangxi Journal of Medical Laboratory Sciences
