摘要
目的探讨血清CA199、CA125和CEA三种指标联合检测对提高胰腺癌诊断性能的价值。方法应用电化学发光免疫分析法检测63例胰腺癌和97例胰腺良性病组(包括急慢性胰腺炎)以及109例正常体检者血清中CA199、CA125和CEA的水平,Logistic回归和ROC曲线分析三者联合检测对胰腺癌诊断性能,评价它们的诊断价值。结果各肿瘤标志物在胰腺癌组浓度均显著高于胰腺良性病组和正常对照组(P<0.05或P<0.01);CA199、CA125和CEA对胰腺癌诊断的灵敏度特异性和准确度分别为82.3%、89.6%、0.837,62.7%、91.8%、0.691和79.4%、90.5%、0.811;Logistic回归和ROC曲线分析三者联合检测对胰腺癌诊断的灵敏度特异性和准确度分别为92.6%、86.5%和0.912。结论 CA199、CA125和CEA联合检测可明显提高胰腺癌诊断的灵敏度,有助于为胰腺癌提供参考诊断。
Objective To evaluate the value of the three serum tumor markers, CA19 - 9,CEA and CA125 in improving the diagnostic performance of pancreatic cancer. Methods The serum concentrations of CA199, CEA and CA125 were measured with electrochemilu- minescence immunoassay in the 93 patients with pancreatic cancer,63 patients with the chronic pancreatitis and 109 normal controls. The value of the three serum tumor markers in the diagnostic performance of pancreatic cancer was evaluate with the ROC curve. Results The concerntrations of these tumor markers in the patients with pancreatic cancer were significantly higher than those in the chronic pancreatitis and normal controls（ P 〈 0.05 or P 〈 0.01 ）. The sensitivity, specificity and accuracy of CA199 ,CEA and CA125 were 82.3% ,89.6% , O. 837 and 62.7% ,91.8% ,0. 691 and 79.4% ,90.5% ,0. 811, respectively. The sensitivity, specificity and accuracy of combined detec- tion of CA199, CA125 and CEA were 92.6% ,86.5% and 0. 912. Conclusion The combined measurement of serum CA199, CA125 and CEA significantly increased the sensitivity for diagnosis of pancreatic cancer and can provide useful information as a diagnosis of the refer- ence in patients with pancreatic cancer.
出处
《医学研究杂志》
2011年第6期147-149,共3页
Journal of Medical Research
