摘要
目的探讨CA199、CA242、CA125、CEA和OPN联合检测对胰腺癌诊断和疗效评价的临床价值。方法检测41胰腺癌患者术前及术后1个月和40例健康体检者外周血清中肿瘤标志物CA199、CA242、CA125、CEA和OPN的水平,比较胰腺癌组术前和术后的变化。并计算肿瘤标志物诊断胰腺癌的敏感性、特异性及准确性。结果胰腺癌组各肿瘤标志物测定值及阳性率明显高于正常对照组,术前测定值明显高于术后,差异有统计学意义,P均<0.05。标志物联合检测的敏感性和诊断准确性均比单项检测高,其中单项以CA199敏感性最高。结论 CA199、CA242、CA125、CEA和OPN联合检测对胰腺癌的诊断、疗效观察及复发预测是较理想的指标,具有重要的临床意义。
Objective To explore the clinical significance of combined detection of serum CA199,CA242,CA125 ,CEA and OPN levels in diagnosis and therapeautic evaluation of pancreatic carcinoma. Methods Detection of Serum tumor markers CA199,CA242,CA125 ,CEA and OPN Were carried out in 41 patients with pancreatic carcinoma and 40 healthy volunteer, and in pancreatic cancer group these tumor markers were detect- ed before operation and 1 month after operation. The sensitivity, specificity and accuracy of the detection in pancreatic cancer diagnosis were calcu- lated. Results The concerntrations of these tumor markers and the positive ratio in the patients with pancreatic cancer were significantly higher than those in the normal controls, The concentrations of the five markers of preoperation are higher than that of postoperation, and difference was sta- tistically significant （all P〈0.05）. If serum CA199, CA242, CA125, CEA and OPN were detected simultaneously, the sensitivity and specificity in di- agnosis of pancreatic cancer could be improved,and sensitivity of CA199 is the highest among those markers. Conclusion The combined detection of serum CA199, CA242, CA125, CEA and OPN levels has better clinical value in diagnosis, therapeutic effect evaluation and prognosis prediction.
出处
《浙江创伤外科》
2012年第3期294-297,共4页
Zhejiang Journal of Traumatic Surgery
