摘要
目的：探索髓核移植接触神经根后对大鼠诱发电位及神经显微结构的影响。方法：20只SD大鼠随机分成2组,A组、B组分别取大鼠自体皮下筋膜脂肪及尾部的髓核组织,无压迫下放置在L45神经根周围。分别在术前、术后即刻、术后3天检测大鼠术侧诱发电位。3天时处死大鼠,进行神经根的病理切片观察。结果：A组大鼠感觉及运动诱发电位手术前后没有明显变化,B组诱发电位潜伏期延长。神经显微结构观察,A组少量炎性细胞浸润,B组神经外膜水肿、大量炎性细胞侵润,髓鞘水肿。结论：髓核接触神经根后可引起神经周围急性炎症病理改变,并引起神经传导功能的下降。
Objective：To explore the evoked potentials and neural microstructure changes in rats after transplantation of autologous nucleus pulposus to nerve root.Methods：20 SD rats were randomly divided into 2 groups.subcutaneous fascia tissue and autologous nucleus pulposus were placed on the L45 nerve root under no pressure,respectively.Evoked potentials were measured before surgery,immediately after the operation,and 3 days after the operation.The rats were killed 3 days after the operation and pathological observation of nerves was done.Results：Longer latency of evoked potential in group B,while no significant change in group A.Epineurial edema,inflammatory cell infiltration,myelin edema were observed in group B.Group A only have a small amount of inflammatory cell infiltration.Conclusion：Transplantation of autologous nucleus pulposus to nerve roots can cause pathological changes of acute inflammation around the nerve and the decline in nerve conduction.
出处
《辽宁中医药大学学报》
CAS
2011年第6期64-66,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
江苏省国际科技合作资助项目(BZ2008071)
关键词
髓核
神经根
诱发电位
病理改变
nucleus
nerve root
evoked potential
pathological changes
