摘要
目的 研究宫颈癌新辅助化疗（ｎｅｏａｄｊｕｖａｎｔｃｈｅｍｏｔｈｅｒａｐｙ，ＮＡＣＴ） 前后肿瘤组织内ＡｇＮＯＲ 颗粒计数和形态的变化。方法 ３１ 例肿块直径≥４ｃｍ 的Ⅰｂ～Ⅱｂ 期宫颈癌患者给予以顺铂为基础的ＮＡＣＴ，３～４ 周后接受子宫广泛切除术。应用Ｐｌｏｔｏｎ’ｓ 方法检测ＮＡＣＴ 前后ＡｇＮＯＲ 计数和形态变化，同时对其组织学疗效进行评价。结果 宫颈癌ＮＡＣＴ 前ＡｇＮＯＲ 颗粒计数为５．０４ ±０．８３ ，ＮＡＣＴ 后为３．２９ ±０．７６ ，两组有非常显著性差异（ Ｐ ＜０．０１） ；ＮＡＣＴ 后，ＡｇＮＯＲ 颗粒形态发生明显变化，单一型和核仁内型所占比例显著上升（ Ｐ ＜ ０．０１） ；组织学无效组，ＮＡＣＴ 前后ＡｇＮＯＲ 颗粒计数也有非常显著性的差异（ Ｐ ＜ ０．００１） 。结论 新辅助化疗对宫颈癌细胞的增殖具有明显的抑制作用。
Objective To study the AgNOR changes of cervical cancer before and after the neoadjuvant chemotherapy(NACT).Methods NACT with cisplatine-based regimen was performed and,3～4 weeks later,radical hysterectomy was done on 31 patients.The tumors staged at Ⅰ b～Ⅱ b whose largest diameter were greater than 4cm.The ploton's method was applied to detect the AgNOR changes of cervical cancer before and after NACT.Histologic changes after NACT were simultaneously recorded.Results AgNOR counts of before and after NACT were 5 04±0 83 and 3 29±0 76 respectively,the difference was significant(P<0 01);After treatment,the AgNOR configuration changed greatly,the rate of simple type or/and within nucleoli one was enhanced significantly(P<0 01);In the noneffective groups of histologic aspect,AgNOR counts after NACT also showed more significant decreasing(P<0 001).Conclusion NACT can inhibit the proliferation of cervical cancer cells.It is recommanded that NACT be employed to be one of combined treatments for cervical cancer with bulky mass.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1999年第10期599-601,共3页
Chinese Journal of Practical Gynecology and Obstetrics
