摘要
目的：探讨ＣＤ４４（ＣＤ４４ｓ 及ＣＤ４４ｖ６）和ｎｍ２３ 基因产物表达与食管癌临床病理指标及预后的关系。方法：应用ＳＰ免疫组化染色法对５４ 例食管癌标本进行ＣＤ４４ 、ｎｍ２３ 基因产物测定，并对其中４１ 例进行了术后３ 年随访。结果：ＣＤ４４ｖ６ 基因产物的高表达和ｎｍ２３ 基因产物的低表达与食管癌的浸润转移、复发和预后均有关（Ｐ＜００５） 。食管癌中ＣＤ４４ｖ６ 和ｎｍ２３ 表达呈负相关（Ｐ＜ ００５）。ＣＤ４４ｖ６ 阳性表达伴ｎｍ２３ 阴性表达的患者发生淋巴结转移的可能性大。结论：ＣＤ４４（ 尤其是ＣＤ４４ｖ６）和ｎｍ２３ 在食管癌中的表达与食管癌的发生发展、侵袭转移和预后密切相关，ＣＤ４４ｖ６ 和ｎｍ２３ 表达在食管癌淋巴结转移中起协同作用。
Objective: To study the expression of CD 44 and nm23 gene products and its clinical significance in esophageal cancer patients (EC) Methods: CD 44 and nm23 expressions were determined in paraffin-embeded tissues from 54 esophageal cancers with immunohistochemical methods Forty-one cases were followed up for 3 years Results: Overexpression of CD 44 v6 gene product and low expression of nm23 gene product were closely related with the invasive extent, metastasis, recurrence and the prognosis of EC ( P <0 05) The expression of CD 44 v6 showed paradoxical relationship with that of nm23 ( P <0 05) Patients with positive CD 44 v6 expression and negative nm23 expression were more likely to have lymph node metastasis Conclusion: The expression of CD 44 and nm23 correlate with the development, invasion , metastasis and prognosis of EC CD 44 and nm23 expressions may serve as an important indicator of metastasis and prognosis of esophageal cancer
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第9期666-669,共4页
Chinese Journal of Clinical Oncology
