摘要
应用免疫组织化学S-P法检测60例贲门癌中肿瘤转移抑制基因表达nm23-H1蛋白的情况。结果发现：癌组织阳性29例（48．33％），nm23-H1蛋白的表达与癌组织的组织学类型及淋巴结转移有关（P＜0．025，P＜0．05），而与癌组织浸润深度无关（P＞0．05）。结果表明，nm23蛋白可作为一种贲门癌淋巴结转移的重要生物学标记物，有助于对贲门癌生物学行为的了解及预后的判断。
Sixty cases of cardinal adenocarcinoma were studied for expression of metastasis suppresser gene nm23 - H1 protein by using immunochemical S-P method. The results showed that 29 cases (48.33%) of cardinal adenocarcinoma were nm23-H1 protein positive, and the nm23-H1 expression was related to histology type and metastasis of lymph nodes in cancer tissues (P<0.025, P<0.05), but not related to the infiltration depth (P<0.05). It was suggested that nm23 might be an important biological marker of metastases of lymph nodes and that it might be useful tothe study of biological behavior and to the judgment of prognosis in cardinal adenocarcinoma.
出处
《汕头大学医学院学报》
1997年第4期1-3,共3页
Journal of Shantou University Medical College
